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56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

rhBMP-2 in posterior lumbar interbody fusion (PLIF)

rhBMP-2 bei dorsaler Spondylodese (PLIF)

Meeting Abstract

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  • corresponding author A. Beier - Klinik für Neurochirurgie, BG-Klinik Bergmannstrost, Halle/Saale
  • T. Ganey - Atlanta Medical Center, Atlanta
  • H. J. Meisel - Klinik für Neurochirurgie, BG-Klinik Bergmannstrost, Halle/Saale

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc09.05.-11.03

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2005/05dgnc0048.shtml

Published: May 4, 2005

© 2005 Beier et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

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Objective

To evaluate whether recombinant bone morphogenetic protein-2 (rhBMP-2) can be substituted for bone autograft during PLIF-technique in spinal surgery.

Methods

We studied the fusion process after implantation of rhBMP-2 in 17 patients with degenerative lumbar spine diseases in combination with dorsal fixation with pedicle screws and poly-ether-ether-ketone (peek) interbody cages. We used 12 mg rhBMP-2 carried by collagen-sponge, 6 mg in every cage. Patient follow-up consisted of pre-operative radiographic and clinical evaluation. Similar post-operative evaluations were performed at 3 and 6 months.

Results

Clinical assessment demonstrated clear improvement in all patients despite the fact that evidence of vertebral endplate osteoclastic activity was apparent in the 3-month radioographs. The 6-month radiographs however, confirmed evidence of fusion.

Conclusions

While former studies have shown exclusively positive results in both fusion rates and process, to date our study has not demonstrated any improvement in ossification using Induct Os in combination with peek-cages using a PLIF-technique. Further studies will be needed to show the potential benefit in comparison to the use of bone-filled cages. Nevertheless, fusion was reached in all cases with a six-month-control, and there was no negative influence on clinical outcome.