Artikel
Treatment of central retinal artery occlusion: Results of a multicenter randomized trial (EAGLE-Study)
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Veröffentlicht: | 18. Juni 2008 |
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For the EAGLE Study Group
Background: To compare the therapeutical efficiacy of local intraarterial fibrinolysis (LIF) versus conservative treatment in patients with an acute central retinal artery occlusion (CRAO) in a prospective, randomised and multicenter trial.
Method: The study was started in 2002. The most important inclusion criterias are: (1) age between 18 – 75 years, (2) CRAO not older than 20 hours and (3) visual acuity < 0.32. Primary study endpoint is the visual acuity before and 1 month after therapy.
Results: The first interim analysis showed similar visual results in both groups and further recruitment was not recommended. Therefore, the EAGLE trial was stopped. Both therapeutic strategies gave better results as compared to natural course. Until December 2007 84 patients of 17 medical centers in Germany, Switzerland and Austria could be included in the study.The final analysis will be finished in May 2008. The results of all 84 included patients will be presented.
Financial support: DFG and Boehringer Ingelheim Pharma KG