Artikel
Biomechanical properties of cartilage repair tissue after different surgical treatments in a sheep model
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Veröffentlicht: | 13. Juni 2005 |
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Gliederung
Text
Introduction
The aim of this study was to evaluate the biomechanical quality of cartilage and repair tissue in a sheep's knee. Two standardized 7 mm defects were created on the medial femoral condyle and patella groove (n=30). These were treated with five different cartilage repair procedures and examined one year later.
Material and Methods
The different groups were: (1) a cell-seeded collagen type I/III matrix (Chondro-Gide®); (2) a cell-seeded collagen type II matrix; (3) microfracture; (4) microfracture and a collagen type I/III matrix (Chondro-Gide®); (5) microfracture and a collagen type II matrix. All matrices were sutured or glued to the defect. As controls we used equivalent cartilage defects in the contralateral knee. Indentation tests were performed over 35 s to calculate the "25s-creep-index" . The elastic modulus was determined on the basis of the instantaneous indentation within the initial 0,25 s.
Results
The untreated defects were filled with less repair tissue than the treated ones. Generally, the repair tissues revealed a lower biomechanical quality compared to native cartilage. There were no significant differences between the treated groups.
Conclusion
In this animal study, none of the induced repair tissues was biomechanically comparable to genuine articular cartilage.