Artikel
Non invasive, reversible and dose dependent titration of blood pressure in cyp1a1ren-2 transgenic rats, a new model for hypertension and associated end organ damage
Nicht-invasive reversible und dosisabhängige Titration des Blutdrucks in Cyp1a1ren-2 transgenen Ratten: a new model for hypertension and associated end organ damage
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Veröffentlicht: | 8. August 2006 |
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Gliederung
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A rat model has recently been generated, in which hypertension can be induced by oral uptake of indol-3-carabinole (I3C). In this model, hepatic expression of a renin gene primarily leads to elevated circulating prorenin levels. We tested whether or not circulating renin levels as well as blood pressure can be titrated with I3C. A dose dependent increase of plasma prorenin levels was observed (3, 10, 30, 100 and 200 fold with 0, 03%, 0, 06%, 0, 08%, 0, 01% and 0, 15% I3C, respectively). Blood pressure increased dose dependently, starting with a threshold level of 0, 08% I3C (+20, +55 and +70 mmHg with 0, 08%; 0,1% and 0,15%, respectively). All effects were reversible even after 2 weeks of induction. The cyp1a1ren-2 transgenic rat thus is a powerful model for cardiovascular disease, since blood pressure can be titrated non-invasively in a tight dose and time-dependent manner.