gms | German Medical Science

29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

Non invasive, reversible and dose dependent titration of blood pressure in cyp1a1ren-2 transgenic rats, a new model for hypertension and associated end organ damage

Nicht-invasive reversible und dosisabhängige Titration des Blutdrucks in Cyp1a1ren-2 transgenen Ratten: a new model for hypertension and associated end organ damage

Meeting Abstract

  • J. Peters - Universität Greifswald (Greifswald, D)
  • O. Grisk - Universität Greifswald (Greifswald, D)
  • B. Becher - Universität Greifswald (Greifswald, D)
  • H. Wanka - Universität Greifswald (Greifswald, D)
  • J.J. Mullins - University of Edinburgh (Edinburg, UK)
  • R. Rettig - Universität Greifswald (Greifswald, D)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP78

The electronic version of this article is the complete one and can be found online at:

Published: August 8, 2006

© 2006 Peters et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



A rat model has recently been generated, in which hypertension can be induced by oral uptake of indol-3-carabinole (I3C). In this model, hepatic expression of a renin gene primarily leads to elevated circulating prorenin levels. We tested whether or not circulating renin levels as well as blood pressure can be titrated with I3C. A dose dependent increase of plasma prorenin levels was observed (3, 10, 30, 100 and 200 fold with 0, 03%, 0, 06%, 0, 08%, 0, 01% and 0, 15% I3C, respectively). Blood pressure increased dose dependently, starting with a threshold level of 0, 08% I3C (+20, +55 and +70 mmHg with 0, 08%; 0,1% and 0,15%, respectively). All effects were reversible even after 2 weeks of induction. The cyp1a1ren-2 transgenic rat thus is a powerful model for cardiovascular disease, since blood pressure can be titrated non-invasively in a tight dose and time-dependent manner.