Artikel
Torasemide Effectively Reduces Pulse Pressure
Torasemid bewirkt eine nachhaltige Senkung des Pulsdruckes
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Autoren
Veröffentlicht: | 11. November 2004 |
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Gliederung
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Objective
Pulse pressure has recently been described as a predictive marker for cardiovascular diseases. As cardiovascular morbidity is reduced by torasemide, a high ceiling long acting loop-diuretic, we investigated the influence of torasemide on pulse pressure.
Methods
In this multicenter observational study, 2,878 patients suffering from cardiovascular diseases (median age 68.3 years, 53.4% women) were enrolled. Of these, 84.7% had an essential hypertension and 60.6% suffered from chronic heart failure. More than half of the enrolled patients (54.1%) were pre-treated with furosemide (median dose 40 mg/d). Patients in whom their physicians considered to prescribe a diuretic were conferred to torasemide (median dose 10.0 mg/d) with a 6-weeks follow-up. Pulse pressure, blood pressure and body weight were documented before torasemide treatment and at follow-up.
Results
After 6 weeks the median reduction in body-weight was 2.00 kg. Median blood pressure reduced from 152.0 to 140.0 mmHg systolic and from 90.0 to 80.0 mmHg diastolic. The median reduction in pulse-pressure was 5.0 mmHg. Pulse pressure reduction was independent of age, gender, body-weight before treatment and diuretic pre-treatment.
Conclusion
In this study, torasemide proved to be an effective diuretic that leads to a significant reduction of pulse pressure even in patients pre-treated with diuretics. Of note, pulse pressure was reduced with torasemide regardless of cardiovascular risk factors.