gms | German Medical Science

27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Liga zur Bekämpfung des hohen Blutdrucks – Deutsche Hypertonie Gesellschaft e. V.

26. bis 29.11.2003, Bonn

Torasemide Effectively Reduces Pulse Pressure

Torasemid bewirkt eine nachhaltige Senkung des Pulsdruckes

Meeting Abstract (Hypertonie 2003)

  • presenting/speaker B. Zegenhagen-Phiong - Berlin-Chemie (Berlin, D)
  • A. Lichtenthal - Berlin-Chemie (Berlin, D)
  • C. Milbredt - Berlin-Chemie (Berlin, D)
  • A. Marx - Berlin-Chemie (Berlin, D)
  • S. Tegeler - Berlin-Chemie (Berlin, D)
  • R. Agrawal - Berlin-Chemie (Berlin, D)

Hypertonie 2003. 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Bonn, 26.-29.11.2003. Düsseldorf, Köln: German Medical Science; 2004. Doc03hochP29

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2003/03hoch129.shtml

Veröffentlicht: 11. November 2004

© 2004 Zegenhagen-Phiong et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

Pulse pressure has recently been described as a predictive marker for cardiovascular diseases. As cardiovascular morbidity is reduced by torasemide, a high ceiling long acting loop-diuretic, we investigated the influence of torasemide on pulse pressure.

Methods

In this multicenter observational study, 2,878 patients suffering from cardiovascular diseases (median age 68.3 years, 53.4% women) were enrolled. Of these, 84.7% had an essential hypertension and 60.6% suffered from chronic heart failure. More than half of the enrolled patients (54.1%) were pre-treated with furosemide (median dose 40 mg/d). Patients in whom their physicians considered to prescribe a diuretic were conferred to torasemide (median dose 10.0 mg/d) with a 6-weeks follow-up. Pulse pressure, blood pressure and body weight were documented before torasemide treatment and at follow-up.

Results

After 6 weeks the median reduction in body-weight was 2.00 kg. Median blood pressure reduced from 152.0 to 140.0 mmHg systolic and from 90.0 to 80.0 mmHg diastolic. The median reduction in pulse-pressure was 5.0 mmHg. Pulse pressure reduction was independent of age, gender, body-weight before treatment and diuretic pre-treatment.

Conclusion

In this study, torasemide proved to be an effective diuretic that leads to a significant reduction of pulse pressure even in patients pre-treated with diuretics. Of note, pulse pressure was reduced with torasemide regardless of cardiovascular risk factors.