Artikel
Concentrations of Moxifloxacin in serum and human aqueous humor following a single 400mg oral dose
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Autoren
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S. Walter
- Department of Ophthalmology, Otto-von-Guericke-University, Magdeburg
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P. Banditt
- Department for Clinical Pharmacology, Otto-von-Guericke-University, Magdeburg
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S.M. Bode-Böger
- Department for Clinical Pharmacology, Otto-von-Guericke-University, Magdeburg
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W. Behrens-Baumann
- Department of Ophthalmology, Otto-von-Guericke-University, Magdeburg
| Veröffentlicht: | 22. September 2004 |
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Gliederung
Text
Objective
The prognosis of visual acuity in bacterial endophthalmitis is poor. The incidence is about 0,1%. Staphylococcus epidermidis and Staphylococcus aureus are the most relevant pathogens for acute forms. Moxifloxacin is a new fluoroquinolone with a broad spectrum of antimicrobial activity. The aim of this study was to assess the concentrations of moxifloxacin in human aqueos humor in comparison to serum concentrations after a single oral dose of 400mg.
Methods
We selected 35 patients, which were scheduled for cataract surgery and who had not received any antibiotics during two weeks prior to surgery. The following time points were chosen between the oral application and the collection of the anterior chamber samples:1, 2, 4, 6, 8, 10 and 12 hours. In addition 10ml venous blood samples were obtained for serum controls. 5 patients were examined in each group. All samples were stored at -20°C until further processing. Moxifloxacin concentrations were determined by high performance liquid chromotography (HPLC) with fluorescence detection.
Results
The serum concentration of moxifloxacin reached a level of 3162ng/ml after 4 hours. The maximum levels of moxifloxacin in the aqueous humor were found 10 hours after application with 1171ng/ml.
Conclusions
These data demonstrate that moxifloxacin following a single 400mg oral dose is enhanced in the none inflamed human eye. These concentrations exceed the MIC90 for anaerobes and also for staphylococcus species. The good aqueos humor penetration could be expected to be even more effective in inflamed eyes like in bacterial endophthalmitis and serious injuries of the eye.
