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57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

11. bis 14.05.2006, Essen

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Increased Biocompatibility of Ion Beam Irradiated ePTFE Polymer for Neurosurgery

Meeting Abstract

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  • corresponding author H. Ujiie - Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University; Beam Technology Team, Advanced Development and Supporting Center, RIKEN
  • Y. Suzuki - Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University; Beam Technology Team, Advanced Development and Supporting Center, RIKEN
  • N. Takahashi - Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University; Beam Technology Team, Advanced Development and Supporting Center, RIKEN
  • T. Hori - Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University; Beam Technology Team, Advanced Development and Supporting Center, RIKEN

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocP 02.19

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2006/06dgnc236.shtml

Veröffentlicht: 8. Mai 2006

© 2006 Ujiie et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

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Objective: Expanded polytetrafluoroethelene (ePTFE) is one of the　biomedical materials most extensively used in surgical repair in various anatomical sites. It is also employed in neurosurgery as replacement prosthesis, mainly as patches to repair defects in dura mater, or as wrapping materials for aneurysms, or to establish a bypass. EPTFE synthesized with polymer CF2 is chemically stable and durable biomaterials because of its fluorine side chain dose not cause immune reaction among the living bodies and stay inert life long period. However, contrary the characteristics advantages of ePTFE such as inertia results in poor adaptability of ePTFE sheets with dura mater and also applied fibrin glue is repelled.

Ion beam irradiation has been developed for implanting impurities in the manufacturing process of semiconductors. Ion beam irradiation has been recognized as a useful method to improve the surface properties of metals without significantly altering the materials’ property. Recently, Suzuki et al has shown that the chemical characteristics of a polymer surface are changed by ion beam irradiation and control of the cell-attachment properties of a polymer surface is possible.

Conclusions: In this report we studied optimal ion beam irradiation technique; ion species, irradiation fluences that makes ePTFE surface biocompatible to improve cell and fibrin glue attachment of ePTFE sheet at in-Vitro and in-Vivo experiments.

Also we report the clinical application of this ion beam irradiated ePTFE for microvascular decompression, repair of a torn artery and hemostasis.