gms | German Medical Science

57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

11. bis 14.05.2006, Essen

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Stereotactic LINAC radiosurgery for glomus jugular tumours: long-term follow-up

Stereotaktische LINAC-Radiochirurgie zur Behandlung von Glomus-Jugulare-Tumoren: Langzeitergebnisse

Meeting Abstract

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  • corresponding author M. Maarouf - Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne
  • F. El Majdoub - Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne
  • H. Treuer - Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne
  • M. Kocher - Department of Radiation Oncology, University of Cologne, Cologne
  • J. Voges - Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne
  • V. Sturm - Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocSO.07.05

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2006/06dgnc204.shtml

Veröffentlicht: 8. Mai 2006

© 2006 Maarouf et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

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Objective: The optimal treatment of glomus jugulare tumours (GJTs) remains controversial. Surgical excision can be associated with a high incidence of cranial nerve injury and decreased quality of life. We present long-term results of LINAC radiosurgery (LINAC-RS) in the management of GJTs.

Methods: From May 1991 through September 2005, 22 GJTs patients (F:M = 18:4, age 29-80 years, median 60 years) were treated with stereotactic LINAC-RS for ongoing growth of either primary tumour or of the residual tumour following surgery. Thirteen of 22 patients with a median follow-up of 7.4 years (range: 5-12 years), were selected for retrospective analysis. A median single dose of 15 Gy (range 11-20 Gy) was applied to the surface of the tumour.

Results: Following LINAC-RS, 9 of the 13 patients (69%) had been improved clinically, 4 (31%) unchanged. Accessible neurological signs improved in 3 (23%) and remained stable in 9 (69%). One patient developed moderate facial nerve palsy (H&B II). MR examinations showed tumour shrinkage in 9 (69%) and no further progression in 4 patients (31%).

Conclusions: This study shows that stereotactic LINAC-RS for GJTs management is safe and highly effective providing long-term tumour control. Thus, radiosurgery is a promising new modality in the management of patients with GJTs and should be included in the discussion of treatment options.

For a good outcome an optimum dose conformation is obligatory, especially for intracranial tumour compartments. The use of a computerized µMLC for LINAC-RS has been encouraging. We expect that computerized µMLC will enable us to treat patients with larger tumours and to reduce radiation-induced side effects by minimizing the radiation exposure to adjacent healthy brain tissue and critical structures.