Artikel
Characterization of hyper- and hypovascularized regions of interest in glioblastoma multiforme by dynamic MR-Imaging, data fusion with preoperatively 3-D-Navigation imaging, and localization of tissue areas with increased/decreased vascularization for molecular quantification of angiogenic cytokines
Charakterisierung hyper- und hypoperfundierter Tumorareale in Glioblastomen mittels dynamischer Magnet-Resonanztomographie (MRT) und navigations-gestützte Entnahme definierter Gewebeareale zur molekularbiologischen Untersuchung
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Autoren
Veröffentlicht: | 23. April 2004 |
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Gliederung
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Objective
Aim of the study was to characterize different vascularized tumor regions in glioblastoma multiforme by dynamic MRI and operative tissue removal by navigation-based microsurgery to allow measurement of different angiogenic cytokines.
Methods
In eight patients with glioblastoma multiforme, a dynamic MRI with Saturation Recovery Turbo-FLASH (SRTF)-Sequence and a high resolution of 1.4 seconds was performed to assess hyper- and hypovascularized areas. In addition, these data were matched to a high resolution 3-D-Navigation imaging and the information was included in a microscopic navigation system (MKM, Zeiss, Oberkochen).
Results
Analysis of image data was conducted by parameter A (amplitude/intensity of the enhancement) and the exchange rate (Interstitial space - intracellular space). In five of eight tumors different angiogenic regions of vascularization could be defined. Regular high values for the amplitude A were found with an average of 0.94±0.71, which often characterizes malignant tumors. All of the included glioblastomas showed at least high values for local areas. The accuracy of the 3-D-Navigation with regard to the anatomic surface of the brain was 2.2mm
Conclusions
Dynamic MRI together with anatomic 3-D-MR imaging data provides a precise identification of hyper- and hypovascularized areas in glioblastomas and allows exact removal of tissue probes for molecular characterization.