gms | German Medical Science

55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

Characterization of hyper- and hypovascularized regions of interest in glioblastoma multiforme by dynamic MR-Imaging, data fusion with preoperatively 3-D-Navigation imaging, and localization of tissue areas with increased/decreased vascularization for molecular quantification of angiogenic cytokines

Charakterisierung hyper- und hypoperfundierter Tumorareale in Glioblastomen mittels dynamischer Magnet-Resonanztomographie (MRT) und navigations-gestützte Entnahme definierter Gewebeareale zur molekularbiologischen Untersuchung

Meeting Abstract

  • A. Huppertz - Molekularbiologisches Labor, Neurochirurgische Universitätsklinik, Ruprecht-Karls-Universität, Heidelberg
  • M. Essig - Molekularbiologisches Labor, Neurochirurgische Universitätsklinik, Ruprecht-Karls-Universität, Heidelberg
  • R. Metzner - Molekularbiologisches Labor, Neurochirurgische Universitätsklinik, Ruprecht-Karls-Universität, Heidelberg
  • R. Wirtz - Molekularbiologisches Labor, Neurochirurgische Universitätsklinik, Ruprecht-Karls-Universität, Heidelberg
  • A. Unterberg - Molekularbiologisches Labor, Neurochirurgische Universitätsklinik, Ruprecht-Karls-Universität, Heidelberg
  • S. Kunze - Molekularbiologisches Labor, Neurochirurgische Universitätsklinik, Ruprecht-Karls-Universität, Heidelberg
  • C. Herold-Mende - Molekularbiologisches Labor, Neurochirurgische Universitätsklinik, Ruprecht-Karls-Universität, Heidelberg
  • corresponding author Hans Herbert Steiner - Molekularbiologisches Labor, Neurochirurgische Universitätsklinik, Ruprecht-Karls-Universität, Heidelberg

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocP 08.88

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2004/04dgnc0371.shtml

Published: April 23, 2004

© 2004 Huppertz et al.
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Outline

Text

Objective

Aim of the study was to characterize different vascularized tumor regions in glioblastoma multiforme by dynamic MRI and operative tissue removal by navigation-based microsurgery to allow measurement of different angiogenic cytokines.

Methods

In eight patients with glioblastoma multiforme, a dynamic MRI with Saturation Recovery Turbo-FLASH (SRTF)-Sequence and a high resolution of 1.4 seconds was performed to assess hyper- and hypovascularized areas. In addition, these data were matched to a high resolution 3-D-Navigation imaging and the information was included in a microscopic navigation system (MKM, Zeiss, Oberkochen).

Results

Analysis of image data was conducted by parameter A (amplitude/intensity of the enhancement) and the exchange rate (Interstitial space - intracellular space). In five of eight tumors different angiogenic regions of vascularization could be defined. Regular high values for the amplitude A were found with an average of 0.94±0.71, which often characterizes malignant tumors. All of the included glioblastomas showed at least high values for local areas. The accuracy of the 3-D-Navigation with regard to the anatomic surface of the brain was 2.2mm

Conclusions

Dynamic MRI together with anatomic 3-D-MR imaging data provides a precise identification of hyper- and hypovascularized areas in glioblastomas and allows exact removal of tissue probes for molecular characterization.