gms | German Medical Science

25th Annual Meeting of the German Retina Society

German Retina Society

01.06. - 02.06.2012, Münster

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Pigment epithelial tears in association with intravtreal ranibizumab therapy of pigment epitheial detachment in AMD: long term visual outcome with OCT based reinjection criteria

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  • Sina Bartels - Augenabteilung am St. Franziskus Hospital Münster
  • M. Gutfleisch - Augenabteilung am St. Franziskus Hospital Münster
  • B. Heimes - Augenabteilung am St. Franziskus Hospital Münster
  • M. Dietzel - Augenabteilung am St. Franziskus Hospital Münster
  • G. Spital - Augenabteilung am St. Franziskus Hospital Münster
  • A. Lommatzsch - Augenabteilung am St. Franziskus Hospital Münster
  • D. Pauleikhoff - Augenabteilung am St. Franziskus Hospital Münster

German Retina Society. 25th Annual Conference of the German Retina Society. Münster, 01.-02.06.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12rg37

doi: 10.3205/12rg37, urn:nbn:de:0183-12rg372

This is the English version of the article.
The German version can be found at: http://www.egms.de/de/meetings/rg2012/12rg37.shtml

Published: May 30, 2012

© 2012 Bartels et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Introduction: Retinal pigment epithelium (RPE) tears may develop as a complication after anti-VEGF-treatment for pigment epithelial detachments (PED) in exudative age-related macular degeneration (AMD). This retrospective study analyses best-corrected visual acuity (BCVA) with OCT based reinjection criteria after RPE tears.

Material and methods: 47 patients with RPE tears during ranibizumab therapy for progressive PED in AMD were included in this monocenter, retrospecitve study. We analyzed BCVA and quantity of injections. Mean follow-up was 81 weeks.

Results: BCVA did not deteriorated after RPE tear and during follow-up significantly (p<0.181). However, if the number of injections within the first year after RIP was less than 3 BCVA deteriorated significantly compared to patients with 3–6 or more injections (p<0.001)

Conclusion: Unter langfristigen, engmaschigen Kontrollen und OCT basierten Wiederbehandlungskritereien war der mittlere Visus im Vergleich zu früheren Verläufen besser. Eine diesem Vorgehen angepasstes Behandlungsschema eines RIPs erscheint deshalb sinnvoll.

With OCT-based reinjection criteria and a long term, regular examination mean BCVA was better compared to previous course of BCVA in the long term. Accordant change of retreatment strategy after RPE tear seams to be reasonable.