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85th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

28.05. - 01.06.2014, Dortmund

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Open, prospective, multicentric study to evaluate the efficacy of postoperative intranasal phototherapy in the prevention of recurrence of nasal polyps

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  • Agnes Kiricsi - University of Szeged Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Szeged, Hungary
  • Zsolt Bella - University of Szeged Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Szeged, Hungary
  • Zsolt Szabó - Dept. of ENT and Operative Dentistry at the Miskolc Hospital of B.A.Z. County, Miskolc, Hungary
  • Lajos Kemény - University of Szeged, Department of Dermatology and Allergy, Szeged, Hungary
  • József Jóri - University of Szeged Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Szeged, Hungary
  • László Rovó - University of Szeged Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Szeged, Hungary
  • Edit Kadocsa - University of Szeged Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Szeged, Hungary

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 85. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Dortmund, 28.05.-01.06.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. Doc14hnod610

doi: 10.3205/14hnod610, urn:nbn:de:0183-14hnod6104

Published: April 14, 2014

© 2014 Kiricsi et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

The therapeutic effect of UV light is generally attributed to its immunosuppressive and immunomodulative effect, by the induction of apoptosis. We have successfully used phototherapy for the treatment of seasonal allergic rhinitis and we found that UV phototherapy induced a dose-dependent increase of eosinophil and T-cell apoptosis.Preliminary open clinical study proved the effect of narrow-band UVB monotherapy on the reduction of nasal obstruction and quality of life by the and of 12-week treatment.

The objective of this study was to evaluate the clinical effect of mixed UV light (Rhinolight®) on the recurrence of nasal polyps during a long (12-week) treatment period with a follow up of 12 months. We have included 30 patients with bilateral recurrent polyposis of age ≥18 and ≤65 years, taking local steroids regularly. They were devided in two groups: Group A they received only intranasal steroid (mometason furoate, 2x200 ug). In Group B they received mixed UV light 3 times per week for 12 weeks and intranasal steroid. We recorded total nasal score, NOSE quality of life, smell thresold test, nasal inspiratory peak flow ,acoustic rhinometry and nasal endoscopy images.

15 patient finished the 12 months procedure completely.4 of 8 patients in the Group B had recurrent polyps 6 months after the phototherapy, in group A instead all of the 7 patients had recurrent polyps. After 12 months in Group B 4 of 8 patients had recurrent polyps, in Group A 6 of 7 patients had recurrent polyps.

Rhinophototherapy with standard nasal steroid may have a supportive role in the treatment of nasal polyposis.

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