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85th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

28.05. - 01.06.2014, Dortmund

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Microvessels and mast cell density in malignant laryngeal neoplasm

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  • corresponding author Nicolae Constantin Balica - Victor Babes University of Medicine and Pharmacy Timisoara, Timisoara, Romania
  • Amalia Raluca Ceausu - Victor Babes University of Medicine and Pharmacy Timisoara, Timisoara, Romania
  • Pusa Gaje - Victor Babes University of Medicine and Pharmacy Timisoara, Timisoara, Romania
  • Marioara Poenaru - Victor Babes University of Medicine and Pharmacy Timisoara, Timisoara, Romania
  • Caius Doros - Victor Babes University of Medicine and Pharmacy Timisoara, Timisoara, Romania
  • Horatiu Eugen Stefanescu - Victor Babes University of Medicine and Pharmacy Timisoara, Timisoara, Romania

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 85. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Dortmund, 28.05.-01.06.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. Doc14hnod178

doi: 10.3205/14hnod178, urn:nbn:de:0183-14hnod1786

Published: April 14, 2014

© 2014 Balica et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Introduction: Laryngeal neoplasm represent 30–40% of the whole head and neck carcinomas. Mast cells are normal connective tissue residents, constantly well represented in respiratory tract. Experimental evidence suggests that the growth of a tumor beyond a certain size requires angiogenesis, which may also permit metastasis. The aim of this study was to evaluate the correlation between mast cell density, microvascular density, histopathological type and histological grade.

Methods: Our study included 38 laryngeal carcinomas. Histopathological diagnosis indicated the presence of the following types: adenoid cystic carcinoma (2 cases), malignant papilloma (4 cases) and squamous cell carcinoma (34 cases). The combined technique CD 34 – Alcian Blue Safranin (AAS) was used for identifying microvessels and mast cells density. Microvessel and mast cell density were calculated using the hot spot method.

Results: A significant correlation was found between mast cell density and G1, G2 histological grade (p=0.002). Partial correlation between microvascular density and G1, G2 histological grade (p=0.004) was noticed. The squamous cell carcinoma histopathological type was significant correlated with mast cell density (p=0.003), but not with the microvascular density (p=0.454).

Conclusions: The correlation between mast cell, microvascular density in the G1, G2 phase indicated a possible promotion of tumor progression by upregulation of angiogenesis.

Unterstützt durch: The German ENT-Society

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