Article
Intranasal trigeminal sensitivity in seasonal allergic rhinitis
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Published: | April 13, 2017 |
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The study aimed at investigating the intranasal trigeminal sensitivity in patients with seasonal allergic rhinitis at 4 different points during the course of 1 year, correlating it to subjective airflow perception, allergic symptoms and endoscopic scores.
Sixteen subjects with birch or grass allergy planned to undergo allergen specific immunotherapy (30.1±6.8 years) and 20 healthy subjects (31.1±9.1years) were included. Intranasal trigeminal sensitivity was tested by means of CO2-thresholds with a standardized device. Sinonasal symptoms were asessed with SNOT-20 questionnaire while endoscopic findings were quantified using Lund-Kennedy-Score. Measurements began before allergy season and were performed every 3 Months. Data was analysed cross-sectional between groups and longitudinal within groups using nonparametric tests.
Before and during allergy season, no significant difference in trigeminal sensitivity, symptom or endoscopic scores was seen between groups, although patients with allergies showed a trend towards reduced trigeminal responsiveness before allergy season, possibly as a sign of chronic irritation. Further on, the distribution of the intranasal trigeminal sensitivity during the course of 1 year after initiation of allergen specific immunotherapy in patients as compared to healthy subjects will be discussed.
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