gms | German Medical Science

87th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

04.05. - 07.05.2016, Düsseldorf

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Neuroprotective Effect of Monomethyl Fumarate on Spiral Ganglion Neurons

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  • author presenting/speaker Christina Ahrensmeier - Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie der Ruhr-Universität Bochum, St. Elisabeth-Hospital, Bochum, Germany
  • Monika Kwiatkowska - Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie der Ruhr-Universität Bochum, St. Elisabeth-Hospital, Bochum, Germany; Univ.-HNO-Klinik Tübingen, Tübungen, Germany
  • Gisa Ellrichmann - Neurologische Universitätsklinik der Ruhr-Universität Bochum, St. Josef Hospital, Bochum, Germany
  • Ralf Gold - Neurologische Universitätsklinik der Ruhr-Universität Bochum, St. Josef Hospital, Bochum, Germany
  • Stefan Dazert - Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie der Ruhr-Universität Bochum, St. Elisabeth-Hospital, Bochum, Germany
  • corresponding author Stefan Volkenstein - Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie der Ruhr-Universität Bochum, St. Elisabeth-Hospital, Bochum, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 87th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Düsseldorf, 04.-07.05.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. Doc16hno17

doi: 10.3205/16hno17, urn:nbn:de:0183-16hno173

Published: September 7, 2016

© 2016 Ahrensmeier et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Introduction: Fumaric acids are well established drugs for Psoriasis treatment and due to their neuroprotective effects for treatment of Multiple sclerosis. In the auditory system, the loss of sensory hair cells induces a progressive degeneration of spiral ganglion neurons (SGN). The only therapeutical options for patients with a severe to profound hearing loss are Cochlear-Implants (CIs). In CIs, the hearing quality depends on the remaining SGN population which are the target cells for electrical stimulation. In this study we aim to investigate the neuroprotective effect of monomethyl fumarate (MMF) on auditory neurons.

Methods: Spiral ganglion neurons of postnatal mice were cultured as single cells, in organotypic explant cultures and in neurosphere assays. After 24 h in organotypic culture cells were exposed to oxidative stress (50 µM H2O2) for 2 h and treated additional 48 h with MMF. Survival and neurite length were measured under MMF towards control groups without MMF treatment by immunohistochemical staining.

Results and conclusion: MMF significantly increased the survival and neurite length in each setting towards the control groups. The neuroprotective effect of MMF on auditory neurons and the associated survival of SGN population may be used in combination with CIs and lead to an improvement of functional results in these patients.

Outline

References

1.
Gillespie LN, Shepherd RK. Clinical application of neurotrophic factors: the potential for primary auditory neuron protection. Eur J Neurosci. 2005 Nov;22(9):2123-33.
2.
Pettingill LN, Richardson RT, Wise AK, O'Leary SJ, Shepherd RK. Neurotrophic factors and neural prostheses: potential clinical applications based upon findings in the auditory system. IEEE Trans Biomed Eng. 2007 Jun;54(6 Pt 1):1138-48.
3.
Wilson BS, Dorman MF. Cochlear implants: current designs and future possibilities. J Rehabil Res Dev. 2008;45(5):695-730.