gms | German Medical Science

84th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

08.05. - 12.05.2013, Nürnberg

Article

Send article

Case report of distant metastases in patients with cutaneous squamous cell carcinoma of the head and neck

Meeting Abstract

Search Medline for

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 84th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Nürnberg, 08.-12.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. Doc13hno07

doi: 10.3205/13hno07, urn:nbn:de:0183-13hno078

Published: July 30, 2013

© 2013 Kofler et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

The cutaneous squamous cell carcinoma is the second most common skin cancer in Europe with a rising incidence. Risk factors are sun exposure, fair skin, sunburn in the childhood, tobacco, tar and arsenic, which can cause a mutation in the tumor suppressor gene p53 and lead to skin cancer. The cutaneous squamous cell carcinoma has a good prognosis, but not in case of lymph node involvement or metastases. Distant metastases for this type of tumorare not usual.

This case report presents two patients with cutaneous squamous cell carcinoma of the head. Both patients were presented in our clinic with parotideal and one of them also with cervical metastases after tumor resection alio loco. We performed a radical parotidectomy with facial reconstruction and ipsilateral MRND followed by postoperative radiotherapy. Seven and six months after completed therapy these patients showed distant metastases of the lower back in the first case and of the liver, lung and bone in the second case.

These two cases report about distant metastases after completed therapy and with locoregional control. Similar cases have not been reported before.

Outline

References

1.
Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med. 2001;344:975-83.
2.
Dinehart SM, Nelson-Adesokan P, Cockerell C, et al. Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis. Cancer. 1997;79:920-3.
3.
Grossman D, Leffell Dj. The molecular basis of nonmelanoma skin cancer: new understanding. Arch Dermatol. 1997;133:1263-70.