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83rd Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

16.05. - 20.05.2012, Mainz

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Mortality and Incidence of laryngeal/ hypopharyngeal carcinoma and oropharyngeal carcinoma in comparison in the period of 1993-2009

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  • corresponding author Katrin Lautenschläger - St. Elisabeth-Krankenhaus, Gynecology, Leipzig, Germany
  • presenting/speaker Franziska Lindner - Univ. HNO-Klinik, Leipzig, Germany
  • presenting/speaker Gunnar Wichmann - Univ. HNO-Klinik, Leipzig, Germany
  • presenting/speaker Andreas Dietz - Univ. HNO-Klinik, Leipzig, Germany
  • presenting/speaker Andreas Boehm - Univ. HNO-Klinik, Leipzig, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 83rd Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Mainz, 16.-20.05.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12hno20

doi: 10.3205/12hno20, urn:nbn:de:0183-12hno202

Published: July 23, 2012

© 2012 Lautenschläger et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Introduction: In the context of a retrospective examination the development of the local incidence of carcinoma of the larynx/ hypopharynx (LH-HNSCC) and oropharynx (O-HNSCC) has been determined. We hypothesized that due to a plus in HPV-associated tumours the local patient population with O-HNSCC has changed.

Material and methods: We performed a retrospective analysis of all patients, who suffered from LH-HNSCC and O-HNSCC and have been treated in in the ENT Department of the University of Leipzig between 1993 to 2009, Data submitted to so called “Gießener tumour documentary system” (GTDS) have been used. These data have been conveyed into an Access- tumordata base and have been completed with additional data out of the clinical documents. The analysis was performed with SPSS 18.0.

Results: In between 1993-2009 out of 4312 patients who have been registered, 1116 suffered from LH-HNSCC and 1181 from O-HNSSC. The local incidence of LH-HNSCC is nearly constant. In contrast, the local incidence of O-HNSSC has increased from 20-25/a up to 75-80/a in 2008 and 2009. At time of diagnosis, 63% of patients with LH-HNSCC have an advanced tumour stage (UICCIII+IV). The age at time of diagnosis is higher in patients with early stages (UICCI+II) with 63.4 years, than in patients with UICCIII+IV (59.9 years). During time, the age at first diagnosis continued to rise overall and in between the groups (93-97 UICC I+II: 63.5, UICC III+IV: 58.9; 98-04: 62.6/ 59.9; 05-09: 64.6/ 60.7). In contrast to the increased age of LH-HNSCC, the age of O-HNSCC is decreasing (93-97: 58.3, 98-04: 57.8, 05-09: 57.0). The percentage of patients with positive risk factor related to tobacco and alcohol consumption is higher in LH-HNSCC (94.0%) than O-HNSCC (88.0%).

Discussion: Even though there is a reasonable suspicion, coherence to HPV cannot be made, because no HPV diagnostics had been performed during the 1990’s. At the same time the socio-economic meaning of O-HNSSC is increasing by raised incidence and earlier age at time of diagnosis. In this background, research related to HPV diagnostic is extremely important to come to an improved treatment of both HPV positive and negative patients.