Article
Dysregulated expression of proteinase inhibitor in the pathogenesis of chronic rhinosinusitis
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Published: | July 23, 2012 |
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Background: Chronic Rhinosinusitis is a multifactorial disease. An altered epithelial function might be one of the factors contributing to the pathophysiology of chronic rhinosinusitis. Spink5 is a protease inhibitor and supposed to be an essential regulator of epithelial integrity. The role of spink5 expression in the pathophysiology of CRS with (CRSwNP) and without nasal polyps (CRSsNP) regarding allergic sensitivity, bronchial asthma and aspirin intolerance is unknown.
Material & Methods: 15 nasal mucosa samples were taken during sinus surgery from individuals with CRSsNP, 59 from patients with CRSwNP, and 30 healthy tissue controls of the inferior turbinate. 36 of these individuals were suffering from allergies, 22 from bronchial asthma, and 18 from aspirin intolerance. All samples were analyzed for their individual spink5 status by polymerase chain reaction.
Results: Spink5 expression levels were decreased in individuals with CRSwNP, especially in those with aspirin intolerance and in individuals with allergies.
Conclusion: Lowered spink5 expression might lead to an altered epithelial barrier function and might be another potential aspect of the pathophysiology of CRS characteristic for aspirin intolerance and allergic sensitivity.