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77th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

24.05. - 28.05.2006, Mannheim

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The expression of classic cadherins in cochlea during chicken embryonic development

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  • corresponding author Hong Wang - Hospital of Otorhinolaryngology, Friedrich Schiller University Jena, Jena, Germany
  • Christoph Redies - Institute of Anatomy I, Friedrich Schiller University Jena, Jena, Germany
  • Hilmar Gudziol - Hospital of Otorhinolaryngology, Friedrich Schiller University Jena, Jena, Germany
  • Jiankai Luo - Institute of Anatomy I, Friedrich Schiller University Jena, Jena, Germany

German Society of Otorhinolaryngology, Head and Neck Surgery. 77th Annual Meeting of the German Society of Otorhinolaryngology, Head and Neck Surgery. Mannheim, 24.-28.05.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06hno036

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hno2006/06hno036.shtml

Published: September 7, 2006

© 2006 Wang et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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The cochlea is a complex sensory organ responsible for sound detection. The interaction of the specialized sensory hair cells with the tectorial membrane is responsible for the onset and tuning of hearing in the Corti organ of the inner ear. In this study, by immunohistochemistry we showed that some classic cadherins were specifically expressed in the different parts of cochlea at embryonic incubation day 11 to 20 during chicken inner ear development. N-cadherin was exclusively expressed in the supporting cells and the tectorial membrane, whereas R-cadherin was expressed in the homogene cells and the tectorial membrane. Furthermore, E-cadherin was present in the entire basilar papilla, in the homogene cells and the tegmentum vasculosum, whereas cadherin-6B was located in the hair cells, and the tegmentum vasculosum. At last, cadherin-7 was expressed in the cochlear ganglion and its neurites. The presence of cadherins in the cochlea during chicken development suggested that cadherins play a role in the normal development of the auditory system, for example, in the formation of the tectorial membrane, the anchorage of the tectorial membrane to the supporting cells, and the guidance of neurites in the cochlear nerve.