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Gesundheit – gemeinsam. Kooperationstagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS), Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), Deutschen Gesellschaft für Epidemiologie (DGEpi), Deutschen Gesellschaft für Medizinische Soziologie (DGMS) und der Deutschen Gesellschaft für Public Health (DGPH)

08.09. - 13.09.2024, Dresden

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Holo-Transcobalamin is not associated with the risk of all-cause mortality in the general population

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  • Paula Stürmer - Institute of Epidemiology, Christian-Albrechts-University Kiel, Kiel, Germany
  • Eike Strathmann - Institute of Epidemiology, Christian-Albrechts-University Kiel, Kiel, Germany
  • Gerald Rimbach - Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Kiel, Germany
  • Katharina Weber - Institute of Epidemiology, Christian-Albrechts-University Kiel, Kiel, Germany
  • Wolfgang Lieb - Institute of Epidemiology, Christian-Albrechts-University Kiel, Kiel, Germany

Gesundheit – gemeinsam. Kooperationstagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS), Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), Deutschen Gesellschaft für Epidemiologie (DGEpi), Deutschen Gesellschaft für Medizinische Soziologie (DGMS) und der Deutschen Gesellschaft für Public Health (DGPH). Dresden, 08.-13.09.2024. Düsseldorf: German Medical Science GMS Publishing House; 2024. DocAbstr. 289

doi: 10.3205/24gmds837, urn:nbn:de:0183-24gmds8370

Published: September 6, 2024

© 2024 Stürmer et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Background & aims: Holo-Transcobalamin (holo-TC) is the biologically active form of vitamin B12, a vitamin essential in human metabolism. The association between vitamin B12 and mortality risk has been controversially reported, whereas the relation between holo-TC and survival is unknown. In a population-based sample (n=862, female share 42.8 %, median age 62.3 years), we related serum holo-TC to the risk of all-cause mortality.

Methods: We measured serum holo-TC by electro-chemiluminescence. Multivariable-adjusted Cox proportional hazards regression models were used to quantify the association between serum holo-TC and all-cause mortality.

Results: Over a median follow-up time of 10.9 years, n=99 individuals died. We did not find significant associations between serum holo-TC and the risk of all-cause mortality, neither in the overall sample, nor in subgroups stratified by sex, diabetes, or hypertension.

Conclusion: The biologically active form of vitamin B12, holo-TC, is not related to the risk of all-cause mortality in a moderate-sized sample from the general population.

The authors declare that they have no competing interests.

The authors declare that a positive ethics committee vote has been obtained.