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Gesundheit – gemeinsam. Kooperationstagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS), Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), Deutschen Gesellschaft für Epidemiologie (DGEpi), Deutschen Gesellschaft für Medizinische Soziologie (DGMS) und der Deutschen Gesellschaft für Public Health (DGPH)

08.09. - 13.09.2024, Dresden

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Familial aggregation of monoclonal gammopathy of undetermined significance (MGUS) in a population-based screening cohort

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  • Lisa Baak - Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, Essen, Germany
  • Sarah Sonntag - Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, Essen, Germany
  • Raimund Erbel - Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, Essen, Germany
  • Jan Dürig - Faculty of Medicine, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany
  • Andreas Stang - Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, Essen, Germany
  • Börge Schmidt - Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, Essen, Germany

Gesundheit – gemeinsam. Kooperationstagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS), Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), Deutschen Gesellschaft für Epidemiologie (DGEpi), Deutschen Gesellschaft für Medizinische Soziologie (DGMS) und der Deutschen Gesellschaft für Public Health (DGPH). Dresden, 08.-13.09.2024. Düsseldorf: German Medical Science GMS Publishing House; 2024. DocAbstr. 551

doi: 10.3205/24gmds739, urn:nbn:de:0183-24gmds7391

Published: September 6, 2024

© 2024 Baak et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Introduction: Prevalence estimates of the precursor condition for multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), differ by age, sex and family history. Aim of the study was to examine whether MGUS prevalence is increased in offspring of MGUS cases utilizing a population-based intergenerational screening cohort study in Germany.

Methods: The Heinz Nixdorf Recall Study was used as index population (n=4814, participants aged 45–75 years at study baseline 2000-2003). The prevalence of MGUS in offspring was assessed utilizing the MultiGenerationStudy (MGS; aged 27-90 years at study baseline 2013-2016), that recruited partners (n=1237) and adult children (n=1660) of the index population. MGUS was determined using a sensitive laboratory screening approach by combining standard serum electrophoresis (SPE) with immunofixation.

Results: In MGUS-children with at least one parent having MGUS (n=142) we found a prevalence of 4.2%, whereas among children with no parent having MGUS (n=1478), the prevalence was considerably lower at 1.3%, yielding an age- and sex-adjusted prevalence ratio (PR) of 2.89 (95% CI: 1.07; 6.65).

Conclusion: Our finding of a ~3-fold higher MGUS prevalence in children of MGUS-affected parents supports previous evidence of familial clustering of MGUS and provides a risk estimate for the general population in Germany.

The authors declare that they have no competing interests.

The authors declare that a positive ethics committee vote has been obtained.