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65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS)

06.09. - 09.09.2020, Berlin (online conference)

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The role of estimands in Neuroscience

Meeting Abstract

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  • Hans Ulrich Burger - Hoffmann-La Roche, Basel, Switzerland

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie. 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS). Berlin, 06.-09.09.2020. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocAbstr. 204

doi: 10.3205/20gmds088, urn:nbn:de:0183-20gmds0881

Published: February 26, 2021

© 2021 Burger.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

The presentation will provide an overview on the choice of estimands in a number of different areas of Neuroscience including neurodegenerative disorders with and without effective symptomatic therapies like Alzheimer's disease and Parkinson's disease, neuro-inflammatory diseases like MS or chronic, non-progressive diseases for symptomatic diseases like migraine, pain indications or schizophrenia. The talk will first provide a general overview on the different aspects of estimands, intercurrent events and the main challenges in defining estimands in these different Neuroscience indications. It then will go deeper in one indication and will provide proposals for a meaningful estimand in this indication including a discussion of the pros and cons associated with it.

The authors declare that they have no competing interests.

The authors declare that an ethics committee vote is not required.