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65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS)

06.09. - 09.09.2020, Berlin (online conference)

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Quantifying replicability and consistency in systematic reviews

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  • Ruth Heller - Tel-Aviv University, Tel-Aviv, Israel

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie. 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS). Berlin, 06.-09.09.2020. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocAbstr. 38

doi: 10.3205/20gmds042, urn:nbn:de:0183-20gmds0428

Published: February 26, 2021

© 2021 Heller.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Systematic reviews are important tools for synthesizing evidence from multiple studies. They serve to increase power and improve precision, in the same way that larger studies can do, but also to establish the consistency of effects and replicability of results across studies. We propose novel tools to quantify replicability of treatment effects and assessment of the consistency of findings. We suggest that these tools accompany the fixed-effect or random-effects meta-analysis, and we show that they convey important additional information for the assessment of the intervention under investigation. We motivate and demonstrate our approach and its implications by examples from systematic reviews from the Cochrane library, and offer a way to incorporate our suggestions in their standard reporting system.

The authors declare that they have no competing interests.

The authors declare that an ethics committee vote is not required.

Outline

References

1.
Jaljuli I, Benjamini Y, Shenhav L, Panagiotou O, Heller R. Quantifying replicability and consistency in systematic reviews [Preprint]. ArXiV. Available from: https://arxiv.org/abs/1907.06856 External link