gms | German Medical Science

MAINZ//2011: 56. GMDS-Jahrestagung und 6. DGEpi-Jahrestagung

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V.
Deutsche Gesellschaft für Epidemiologie e. V.

26. - 29.09.2011 in Mainz

Vitamin D status and incident myocardial infarction in the Potsdam-arm of the European Prospective Investigation into Cancer and Nutrition: a pilot nested case-control study

Meeting Abstract

  • Brian Buijsse - Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE), Nuthetal
  • Cornelia Weikert - Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE), Nuthetal
  • Hirche Frank - Institut für Agrar- und Ernährungswissenschaften, Humanernährung, Martin-Luther-Universität Halle-Wittenberg, Halle (S)
  • Jutta Dierkes - Institute of Medicine, University of Bergen, Bergen (Norwegen)
  • Gabriele Stangl - Institut für Agrar- und Ernährungswissenschaften, Humanernährung, Martin-Luther-Universität Halle-Wittenberg, Halle (S)
  • Heiner Boeing - Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE), Nuthetal

Mainz//2011. 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi). Mainz, 26.-29.09.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11gmds310

doi: 10.3205/11gmds310, urn:nbn:de:0183-11gmds3101

Published: September 20, 2011

© 2011 Buijsse et al.
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Outline

Text

Vitamin D may lower the risk of cardiovascular diseases. In a BMBF-funded project, we are currently investigating whether vitamin D status relates to the risk of cardiovascular diseases in the German arm of the European Prospective Investigation into Nutrition and Cancer (EPIC). The current analysis was based on a pilot nested case-control study on vitamin D status and incident myocardial infarction (MI) within EPIC-Potsdam. Included were 100 people who had suffered an MI during ~8 years of follow-up and 200 people who remained free of cardiovascular diseases during this period. 25-hydroxyvitamin D2 (25(OH)D2) and D3 (25(OH)D3) were measured by HPLC-MS/MS and parathyroid hormone (PTH) by ELISA in citrate-plasma samples that had been stored at –196 degrees Celsius since baseline (1994-1998) for about 15 years. 25(OH)D2 was detected in only 8 people (2.7%). 25(OH)D3 was detected in all people and followed a normal seasonal variation. Incident cases of MI had a lower mean 25(OH)D3 concentration than did controls (difference in means: –1.4 ng/ml, 95% confidence interval (CI), –3.1 to 0.3 ng/ml). Odds ratios (95% CIs) for increasing quartiles of 25(OH)D3 adjusted for age, sex, and season of blood draw were 1.0 (referent), 0.95 (0.44 to 2.07), 0.70 (0.31 to 1.59), and 0.41 (0.16 to 1.06). In a similar model with 25(OH)D3 in its continuous scale, the odds of MI decreased with 5% per 1-ng/ml increment in 25(OH)D3 (odds ratio 0.95, 95% CI 0.90 to 1.00). In controls, 25(OH)D3 was weakly inversely correlated with PTH (Spearman’s r=–0.12), though the inverse association between 25(OH)D3 and incident MI remained essentially similar after additional adjustment for PTH (odds ratio per 1-ng/ml 0.95, 95% CI 0.90 to 0.99). Our findings indicate that 25(OH)D3 can successfully be measured in long-term stored citrate plasma. They also confirm earlier studies that found an inverse association with the risk of MI. Concentrations of 25(OH)D2 appear to be too low to detect in this sample. In the near future we will increase the sample size and also include the EPIC-Heidelberg cohort. We will evaluate whether the inverse association is independent of other risk factors for cardiovascular diseases and will also include incident stroke and diabetes as outcome. In addition, we will also use genetic variants in genes involved in vitamin D metabolism to assess the causal role of vitamin D in the prevention of these diseases. Funded by grant FZK0315668 of the German Federal Ministry of Education and Research (BMBF).