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Kongress Medizin und Gesellschaft 2007

17. bis 21.09.2007, Augsburg

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Genetic variants in the USF1 gene are not associated with MetS, T2DM, and related parameters in Caucasians (KORA study)

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  • Christina Holzapfel - GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg
  • Norman Klopp - GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg
  • Harald Grallert - GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg
  • Cornelia Huth - GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg
  • Christian Gieger - GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg
  • Christa Meisinger - GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg
  • Klaus Strassburger - Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at Heinrich-Heine-University, Düsseldorf
  • Guido Giani - Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at Heinrich-Heine-University, Düsseldorf
  • H.-Erich Wichmann - GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg
  • Christian Herder - German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich-Heine-University, Düsseldorf
  • Wolfgang Rathmann - Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at Heinrich-Heine-University, Düsseldorf
  • Thomas Illig - GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg

Kongress Medizin und Gesellschaft 2007. Augsburg, 17.-21.09.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. Doc07gmds567

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/gmds2007/07gmds567.shtml

Published: September 6, 2007

© 2007 Holzapfel et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Background: Upstream stimulatory factor 1 (USF1) regulates numerous genes of glucose and lipid metabolism and genetic variants in the USF1 gene show association with familial combined hyperlipidemia (FCHL), which shows phenotypic overlap with the metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). The aim of our study was to approve the hypothesis that polymorphisms in the USF1 gene are associated with MetS and related metabolic traits.

Materials and methods: We genotyped eight single nucleotide polymorphisms (SNPs) in the USF1 gene in 1,653 individuals of the population-based German Caucasian KORA study in the age range between 55 and 74 years. Because of high correlation only six polymorphisms were statistically analyzed. The association with T2DM and the MetS was analyzed by logistic regression in 1,462 subjects and the quantitative parameters were analyzed in 1,231 fasting non diabetic subjects by linear regression respectively by Kruskal-Wallis test.

Results: None of the analyzed genetic variants (rs2774279, rs10908821, rs1556259, rs2516839, rs3737787, rs2774276) show significant association with T2DM and MetS. The results for the metabolic traits like triglyzerides, total cholesterol, HDL (high density lipoprotein) cholesterol, LDL (low density lipoprotein) cholesterol, percent body fat, waist to hip ratio, ureic acid, fasting glucose, 2 hour plasma glucose, fasting insulin, blood pressure (systolic and diastolic) give also no evidence for any association with USF1.

Conclusion: In our large population based study no association between single genetic variants in the USF1 gene and T2DM, MetS and related metabolic parameters was found. We conclude that the single genetic variants in USF1 have no major effect on lipid and glucose parameters in German Caucasians.