Article
Particulate Air Pollution and Health: Contribution of Epidemiology
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Published: | September 8, 2005 |
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Outline
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Associations have been observed between ambient concentrations of particulate matter and morbidity and mortality consistently and coherently in epidemiological studies. These effects seemed to be attributable to fine particles (diameter below 2.5µm) when measurement techniques were employed. The effects were attributable to respiratory disease exacerbation as well as cardiovascular disease exacerbation. The exacerbation of cardiovascular disease by exposures to ambient particles was long debated due to the missing evidence for biological plausibility. Recent epidemiological studies investigating the biological mechanisms which might be responsible for linking deposition of particles in the lung to cardiovascular disease outcomes have suggested several pathways for particle action. Epidemiological research has generated hypotheses which are currently investigated in studies using controlled animal and human exposures. These potential mechanisms include an acute phase response leading to increases in systemic marker of inflammation in the blood, modification of the autonomic control of the heart and induction of endothelial dysfunction. These changes might predispose individuals to acute ischemia or to sudden cardiac death as indicated by the time-series analyses and case-crossover studies. Unclear is so far, which role the different components of the complex particle mixture play. Ultrafine particles with a diameter below 100 nm have been implicated as being a class of particles with independent health effects. The limited body of studies including ultrafine measurements suggest that there might be health effects of ultrafine and fine particles independently of each other and potentially through different mechanisms. Further epidemiological studies characterising the aerosol with respect to its physico-chemical characteristics are needed to evaluate the role of freshly and locally produced ambient particles in the ultrafine mode.