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21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin e. V.

Deutsches Netzwerk Evidenzbasierte Medizin e. V.

13. - 15.02.2020, Basel, Schweiz

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Evidence Map of Pancreatic Surgery – Living Systematic Review and Meta-Analysis

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  • Pascal Probst - University of Heidelberg, Department of General, Visceral and Transplantation Surgery, Heidelberg, Deutschland; University of Heidelberg, The Study Center of the German Surgical Society (SDGC), Heidelberg, Deutschland
  • Felix J. Hüttner - University of Heidelberg, Department of General, Visceral and Transplantation Surgery, Heidelberg, Deutschland; University of Heidelberg, The Study Center of the German Surgical Society (SDGC), Heidelberg, Deutschland
  • Oemer Meydan - University of Heidelberg, The Study Center of the German Surgical Society (SDGC), Heidelberg, Deutschland
  • Eva Kalkum - University of Heidelberg, The Study Center of the German Surgical Society (SDGC), Heidelberg, Deutschland
  • André L. Mihaljevic - University of Heidelberg, Department of General, Visceral and Transplantation Surgery, Heidelberg, Deutschland; University of Heidelberg, The Study Center of the German Surgical Society (SDGC), Heidelberg, Deutschland
  • Thilo Hackert - University of Heidelberg, Department of General, Visceral and Transplantation Surgery, Heidelberg, Deutschland
  • Markus W. Büchler - University of Heidelberg, Department of General, Visceral and Transplantation Surgery, Heidelberg, Deutschland
  • Markus K. Diener - University of Heidelberg, Department of General, Visceral and Transplantation Surgery, Heidelberg, Deutschland; University of Heidelberg, The Study Center of the German Surgical Society (SDGC), Heidelberg, Deutschland

Nützliche patientenrelevante Forschung. 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin. Basel, Schweiz, 13.-15.02.2020. Düsseldorf: German Medical Science GMS Publishing House; 2020. Doc20ebmS5-V2-01

doi: 10.3205/20ebm032, urn:nbn:de:0183-20ebm0320

Published: February 12, 2020

© 2020 Probst et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Background/research question: Pancreatic surgery is a large and complex field of research. Several evidence gaps exist for specific diseases or surgical procedures. An overview on existing knowledge is needed to plan and prioritise future research. The aim of this project is to create a systematic and living evidence map of pancreatic surgery.

Methods: PubMed, CENTRAL and Web of Science were searched systematically for all randomised controlled trials (RCT) and systematic reviews (SR) on pancreatic surgery. Outcomes and quality of every existing RCT were extracted. SR were used to identify lack of high-quality trials. A web-based evidence map in the format of a mind map was created including meta-analyses of pancreas-surgery specific outcomes for every research topic.

Results: From over 30´000 articles 246 RCT on 26´154 patients and 220 SR were included and grouped in over 50 different research topics. Most trials were conducted in Europe (46%), followed by Asia (35%) and North America (14%). As an example, the pooled rate of postoperative pancreatic fistula in 9555 partial pancreatoduodenectomy patients was 15% (99%-CI 12%-17%). The overall quality of the included RCT was moderate. A lack of evidence exists for operations other than pancreatoduodenectomy and for specific diseases such as neuroendocrine neoplasms or intraductal papillary mucinous neoplasms.

Conclusion: The evidence map of pancreatic surgery gives a systematic and comprehensive overview of the available literature. The pooled estimates of outcomes provide prospectively assessed benchmarks. The intuitive display of the existing literature uncovers evidence gaps and serves as an objective basis for decisions about future research priorities. The web-based evidence map will be accessible in spring 2020 (https://www.evidencemap.surgery/).

Competing interests: Keine