gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

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Application of anti-CD20-antibody in the treatment of recurring conjunctival lymphoma

Meeting Abstract

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  • corresponding author U. Wiehler - Augenklinik mit Poliklinik, Universität Heidelberg
  • T. Möhler - Medizinische Klinik und Poliklinik, Universität Heidelberg
  • G. Mechtersheimer - Pathologisches Institut, Universität Heidelberg
  • H.E. Völcker - Augenklinik mit Poliklinik, Universität Heidelberg
  • S. Dithmar - Augenklinik mit Poliklinik, Universität Heidelberg

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogP 192

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dog2004/04dog683.shtml

Published: September 22, 2004

© 2004 Wiehler et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective

Rituximab is a monoclonal anti-CD20-antibody that has been used as monotherapy or in combination with chemotherapy for some subgroups of recurring non-hodgkin-lymphoma (follicular lymphoma, diffuse large lympoma). We present the first use of this antibody for recurring conjunctival lymphoma.

Methods

In a 41-year-old male patient a low grade B-cell lymphoma of the conjunctiva (extranodal marginal zone B-cell lymphoma of MALT-type with expression of CD20 and bcl-2) was diagnosed in 1990 and treated with radiotherapy (28 Gy). A recurrence on both sides in 1996 was again treated with radiotherapy (28 Gy). Another recurrence was treated with subconjunctival interferon in 1997. Further recurrences (1999, 2002, 2003) were treated with 15 courses of chemotherapy. Another histologically confirmed recurrence (10/2003) was treated with Rituximab 375mg/m2 intravenously once a week for 4 weeks (February 2004). After a slight allergic reaction after the first infusion the further treatment was well tolerated. After a period of 4 weeks a significant subjective improvement and an involution of the conjunctival lymphoma were remarked.

Conclusions

Treatment of recurring conjunctival lymphoma with anti-CD20-antibody seems to be promising.