gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Is there an overlap between APMPPE and serpiginous chorioretinitis?

Meeting Abstract

  • corresponding author M. Zierhut - Universitäts-Augenklinik, Abteilung I, Tübingen
  • F. Gelisken - Universitäts-Augenklinik, Abteilung I, Tübingen
  • M. Völker - Universitäts-Augenklinik, Abteilung I, Tübingen
  • C.M.E. Deuter - Universitäts-Augenklinik, Abteilung I, Tübingen

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.15.11

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2004

© 2004 Zierhut et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




Following the literature acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and serpiginous chorioretinitis are two separat disorders. Recently an overlap between both disorders has been published, characterized by descrepancies between clinical findings and prognosis typically found in both entities. In this regard our patients have been analysed.


Retrospectively we analysed 17 patients with APMPPE and 13 patients with serpiginous (observation period at least 3 months). The following criteria were regarded to be untypical for APMPPE: untypical fluoresceineangiogram, bad visual outcome due to macular involvement, central membrane formation or recurrences. Untypical for serpiginous: untypical fluoreceineangiogram, excellent therapy response with good visual outcome, clinical aspect like APMPPE with progress to serpiginous.


In our analysis, 7 (41%) patients with APMPPE were regarded as untypical (recurrences in 4, contradiction between clinical aspect and fluoresceineangiogram in 4 patients, massively reduced visual acuity due to macular changes) and 5 (38%) patients with serpiginous (contradiction between clinical aspect and fluoresceineangiogram in 4 patients, good visual outcome despite macular changes).


Our study demonstrates that APMPPE, being described as disease with favourable outcome, can progress into serpiginous chorioretinitis in between months. On the other side, serpiginous can have signs of APMPPE. Even at the begin of the disease patients with APMPPE should be controlled often and receive antiinflammatory therapy. Serpiginous seems to response at least mildly to this treatment.