gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

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Role of factor V Leiden, PAI-1 4G/5G and Glycoprotein Ia/IIa 807C>T gene polymorphisms in central retinal vein occlusion

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  • corresponding author I. Steinbrugger - Universitätsklinik für Augenheilkunde, Medizinische Universität Graz, Graz/A
  • M. Weger - Universitätsklinik für Augenheilkunde, Medizinische Universität Graz, Graz/A
  • W. Renner - Klinisches Institut für Medizinische und Chemische Labordiagnostik, Medizinische Universität Graz, Graz/A
  • L. Cichocki - Medizinische Universitätsklinik, Medizinische Universität Graz, Graz/A
  • W. Temmel - Universitätsklinik für Augenheilkunde, Medizinische Universität Graz, Graz/A
  • O. Schmut - Universitätsklinik für Augenheilkunde, Medizinische Universität Graz, Graz/A
  • A. Haas - Universitätsklinik für Augenheilkunde, Medizinische Universität Graz, Graz/A

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.01.03

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dog2004/04dog164.shtml

Published: September 22, 2004

© 2004 Steinbrugger et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

Central retinal vein occlusion (CRVO) is a common cause for a severe visual loss affecting primarily patients older than 50 years. The precise contribution of thrombophilic gene polymorphisms to the development of CRVO is yet to be determined. The purpose of the present study was therefore to investigate the possible role of three common thrombophilic gene polymorphisms- factor V Leiden, PAI-1 4G/5G and glycoprotein Ia/IIa 807C>T - in CRVO.

Methods

The present study was designed as a case-control study including 176 patients with CRVO and 150 control subjects. Genotypes were determined by polymerase chain reaction.

Results

Mean age of patients with CRVO was 67.0±14.5 years and 69.7±12.1 years in control subjects. Genotype distribution of the investigated polymorphisms did not significantly differ between patients and control subjects (Factor V Leiden: 9 vs. 12, p=0.41; PAI-1 4G/4G: 44 vs. 50, p=0.13; GpIa/IIa 807TT: 28 vs. 23, p=1.0). Furthermore, the prevalence of arterial hypertension and diabetes mellitus was not significantly different between both groups.

Conclusions

None of the investigated gene polymorphisms seems to play a major role in the pathogenesis of CRVO.