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Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014)

28.10. - 31.10.2014, Berlin

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Pregabalin is superior than gabapentin in treating spinal morning stiffness pain originated from lumbar disc degeneration

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  • presenting/speaker Georgios Mouzopoulos - Kythira General Hospital, 80100, Greece
  • Ioannis Skevofilax - Chios General Hospital, Chios, Greece
  • Panagiotis Papagiannopoulos - Niebüll Klinik, Nordfriesland Klinikum, Niebüll, Germany
  • Anastasia Tsembeli - Kythira General Hospital, 80100, Greece
  • Georgios Nomikos - Chios General Hospital, Chios, Greece
  • Vasilios Vasiliadis - Chios General Hospital, Chios, Greece

Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014). Berlin, 28.-31.10.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. DocPO16-847

doi: 10.3205/14dkou660, urn:nbn:de:0183-14dkou6600

Published: October 13, 2014

© 2014 Mouzopoulos et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Purpose: To determine the efficacy of pregabalin vs gabapentin in treating morning lumbar spine stiffness pain attributed to lumbar disc degeneration.

Methods/subjects: A study of 96 patients with lumbar spine morning stiffness, presenting to our department, during the period between January 2009 and May 2013, were included. All patients were randomly assigned to receive either 300mg pregabalin daily (Group 1) or gabapentin 1200mg daily (Group 2) for 2 months. Clinical outcomes were measured with VAS pain scale and Roland-Morris Disability Questionnaire at baseline, 6 months, 1 and 2 years after. Statistical analysis was performed by statistical packet STATA 8.0 and significance was set at p-value <0.05.

Results: The VAS pain score decreased significantly from 7.5/10 to 2.3/10 in Group 1 (P<0.05) and from average 7.3/10 to 5.1/10 in Group 2 (p<0.05) at 2 years follow up. Roland Morris Disability decreased also significantly from average 17.8/24 to 2.4/24 in Group 1 (p<0.05) and from 17.1/24 to 6.2/24 in Group 2 (p<0.05) at 2 years follow up. Better clinical outcomes were observed in Group 1 (p<0.05).

Conclusion: Therapy with pregabalin provides efficient pain relief in patients suffering from lumbar spine morning stiffness.