Article
Single-nucleotide polymorphism (SNP) of ABCB1 transporter in colorectal cancer patients and relation to the pharmacokinetics of irinotecan
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Published: | March 20, 2006 |
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P-glycoprotein, the protein product of human multidrug-resistance (ABCB1) gene, is an important efflux pump for many common drugs, including anticancer drugs like irinotecan, doxorubicin and paclitaxel. ABCB1 gene polymorphism may be also involved in modulating interindividual susceptibility to certain diseases. In an ongoing project supported by German Cancer Aid (grant AZ-70-2445-Hö3) we studied a major known single nucleotide polymorphism (C3435T in Exon 26) in 67 patients. The detected genotype variant frequencies were as follows: CC in 28.4%, CT in 46.3 %, and TT in 25.4%. The frequency of the C- allele (51.5%) and of the genotypes were comparable to reported data of white subjects in Western Europe. In 18 patients we investigated the pharmacokinetics of irinotecan. We did not identify correlations between genotypes of C3435T and AUC of irinotecan. Our findings suggest that studied ABCB1 polymorphism did not influence the systemic exposure of irinotecan in colorectal cancer patients.