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Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Thoraxchirurgie

24.-26.10.2013, Basel, Schweiz

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Mutation in KRAS prognosticates early recurrence in patients undergoing pulmonary metastasectomy from primary colorectal carcinoma

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  • T. Schweiger - Division of Thoracic Surgery, Medical University of Vienna, Vienna; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna
  • B. Hegedüs - Division of Thoracic Surgery, Medical University of Vienna, Vienna
  • C. Nikolowsky - Medical University of Vienna, Vienna; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna
  • Z. Hegedüs - 2nd Department of Pathology, Semmelweis University, Budapest
  • P. Birner - Clinical Institute of Pathology, Medical University of Vienna, Vienna
  • B. Döme - Division of Thoracic Surgery, Medical University of Vienna, Vienna
  • R. Mair - Division of Thoracic Surgery, Medical University of Vienna, Vienna
  • G. Lang - Division of Thoracic Surgery, Medical University of Vienna, Vienna
  • W. Klepetko - Division of Thoracic Surgery, Medical University of Vienna, Vienna
  • H. J. Ankersmit - Division of Thoracic Surgery, Medical University of Vienna, Vienna; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna
  • K. Hoetzenecker - Division of Thoracic Surgery, Medical University of Vienna, Vienna

Deutsche Gesellschaft für Thoraxchirurgie. Österreichische Gesellschaft für Thoraxchirurgie. Schweizerische Gesellschaft für Thoraxchirurgie. Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Thoraxchirurgie. Basel, Schweiz, 24.-26.10.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocP25

doi: 10.3205/13dgt075, urn:nbn:de:0183-13dgt0750

Published: October 14, 2013

© 2013 Schweiger et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: Pulmonary metastasectomy is an integral part of the interdisciplinary treatment of patients with primary colorectal carcinoma (CRC) and pulmonary metastases (PM). KRAS mutations are evident in about one third of primary CRC tissue samples, however, the prognostic value of these mutations in the primary tumor has been questioned. We hypothesized, that KRAS mutation status might be a potential prognostic marker in the subset of patients undergoing pulmonary metastasectomy.

Methods: DNA was isolated from tissue specimens of thirty-nine patients with primary CRC and PM. RT-PCR was used for KRAS codons 12 and 13 mutation analysis.

Results: Mutations in KRAS codon 12 and 13 was detected in 43.6% and 5.1%, respectively, of the PM specimens. The occurrence of first PM did not differ between mutant and wild-type groups. However, mutations in KRAS were strongly associated with early post-metastasectomy recurrence after the first pulmonary metastasectomy (HR 2.94 (95%CI 1.13–7.67); p=0.030).

Conclusion: In this work we describe for the first time KRAS mutations in the context of pulmonary metastasectomy in patients with primary CRC and PM. Our data suggest that patients with KRAS mutations should be followed-up very carefully, as early recurrence after pulmonary metastasectomy seems to be associated with this genotype.