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Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Thoraxchirurgie

24.-26.10.2013, Basel, Schweiz

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Heat-shock proteins 27 and 70 in primary colorectal cancer and corresponding pulmonary metastases

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  • T. Schweiger - Division of Thoracic Surgery, Medical University of Vienna, Vienna; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna
  • D. Traxler - Division of Thoracic Surgery, Medical University of Vienna, Vienna; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna
  • C. Nikolowsky - Division of Thoracic Surgery, Medical University of Vienna, Vienna; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna
  • G. Lang - Division of Thoracic Surgery, Medical University of Vienna, Vienna
  • P. Birner - Clinical Institute of Pathology, Medical University of Vienna, Vienna
  • W. Klepetko - Division of Thoracic Surgery, Medical University of Vienna, Vienna
  • B. Hegedues - Division of Thoracic Surgery, Medical University of Vienna, Vienna
  • B. Dome - Division of Thoracic Surgery, Medical University of Vienna, Vienna
  • K. Hoetzenecker - Division of Thoracic Surgery, Medical University of Vienna, Vienna; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna
  • H. J. Ankersmit - Division of Thoracic Surgery, Medical University of Vienna, Vienna; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna

Deutsche Gesellschaft für Thoraxchirurgie. Österreichische Gesellschaft für Thoraxchirurgie. Schweizerische Gesellschaft für Thoraxchirurgie. Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Thoraxchirurgie. Basel, Schweiz, 24.-26.10.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocF 3

doi: 10.3205/13dgt003, urn:nbn:de:0183-13dgt0030

Published: October 14, 2013

© 2013 Schweiger et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: Heat-shock proteins (HSP) 27 and 70 are involved in anti-apoptotic mechanisms during cellular stress. By this mechanism their expression is related to rapid tumor progression. Pulmonary metastases (PM) occur frequently in patients with primary colorectal cancer (CRC) und surgical resection is routinely performed in these patients. We sought to investigate the prognostic implication of HSP27 and 70 in patients undergoing pulmonary metastasectomy.

Methods: PM of forty-four patients with primary colorectal carcinoma (CRC) were assessed by immunohistochemistry. Furthermore, corresponding primary CRC of thirty-two patients were available. Expression of HSP27, HSP70 and alpha-smooth muscle actin was correlated with clinical parameters.

Results: HSP27 and HSP70 were evident in 90.6% and 96.9% of primary tumors and in 72.7% and 95.5% of paired PM. In general, correlation between primary tumor and paired metastases was poor. Lung-metastasis free survival was significantly shorter in patients with high levels of HSP70 and low levels of HSP27 in tumor cells of PM. Interestingly, co-expression of HSP27 and alpha-smooth muscle actin in activated tumor-associated fibroblasts in PM was associated with both, decreased lung-metastasis free survival and lung-specific recurrence free survival in univariate analysis.

Conclusion: This study provides first evidence of HSP in tumor cells and tumor-associated fibroblasts in PM of primary CRC. Our data indicate an association between cellular stress of and early pulmonary spreading and lung-specific recurrence. In the future, HSP27 and HSP70 might also pose promising therapeutic targets in patients with PM of CRC.