gms | German Medical Science

Deutscher Rheumatologiekongress 2024

52. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh)
34. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
38. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

18.09. - 21.09.2024, Düsseldorf

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Dysregulation of amino acid and lipid metabolism in axial and peripheral spondyloarthritis

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  • Constantin Remus - Medical School Brandenburg, Brandenburg
  • Meike Hoffmeister - Medical School Brandenburg, Brandenburg
  • Inga Claus - Medical School Brandenburg, Brandenburg
  • Selina Strathmeyer - lifespin, Regensburg
  • Steffen Heelemann - lifespin, Regensburg
  • Werner Dammermann - Medical School Brandenburg, Brandenburg
  • Oliver Ritter - Medical School Brandenburg, Brandenburg
  • Daniel Patschan - Medical School Brandenburg, Brandenburg
  • Susann Patschan - Medical School Brandenburg, Brandenburg

Deutsche Gesellschaft für Rheumatologie. Deutsche Gesellschaft für Orthopädische Rheumatologie. Gesellschaft für Kinder- und Jugendrheumatologie. Deutscher Rheumatologiekongress 2024, 52. Kongress der Deutschen Gesellschaft für Rheumatologie und Klinische Immmunologie (DGRh), 34. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR), 38. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh). Düsseldorf, 18.-21.09.2024. Düsseldorf: German Medical Science GMS Publishing House; 2024. DocSpA.34

doi: 10.3205/24dgrh190, urn:nbn:de:0183-24dgrh1902

Published: September 18, 2024

© 2024 Remus et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Introduction: Spondyloarthritis (SpA), also known as seronegative spondylarthropathy, can be classified into axial or peripheral types according to established criteria. In recent years, metabolomics has been increasingly used to identify potential biomarkers and investigate the underlying mechanisms of inflammatory and non-inflammatory diseases. The aim of this study was to perform metabolomic profiles in both axial and peripheral SpA patients in comparison to healthy subjects.

Methods: Observational, cross-sectional study that included patients with both axial spondyloarthritis (ankylosing spondylitis: AS – respectively axSpA and nr-axSpA) and peripheral spondyloarthritis (psoriatic arthritis: PsA). Healthy individuals, matched for age and gender, were included as controls. Metabolomic profiling was conducted using a Bruker AVANCE NEO 600 MHz NMR spectrometer. The spectra obtained were Fourier transformed using TopSpin software (version 4.0, Bruker Biospin, Germany). All spectra were automatically phased and subjected to baseline correction. Subsequently, the spectra were analyzed using the proprietary Profiler software (version 1.4_Blood, lifespin GmbH, Germany) and a quantitative metabolite list was generated.

Results: A total of 50 patients with AS and 50 individuals with PsA were included in the study, with 164 individuals serving as controls. In the group of patients with AS, there were significant differences in 46 metabolites predominantly related to amino acid and lipid metabolism compared to healthy controls. PsA subjects showed differences in a total of 31 metabolites compared to controls. However, only two differences were found between AS and PsA, specifically in glucose and glycerol levels. No differences were identified within the SpA cohorts in terms of disease-modifying antirheumatic drug (DMARD) management.

Conclusion: Our data indicate significant aberrations in amino acid and lipid metabolism in SpA patients. The large number of identified metabolites opens up promising perspectives, not only regarding the identification of new SpA biomarkers but also in terms of understanding the pathophysiology of these chronic inflammatory diseases more in detail.