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Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

15.09. - 18.09.2021, virtuell

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Acute response of a soluble cartilage degradation marker to a 30-minute walking exercise is similar in patients at risk of RA compared to patients with established RA

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  • Anna-Maria Liphardt - Medizinische Klinik 3, Rheumatologie und Immunologie, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen
  • Lisa Bleckwedel-Rolack - Medizinische Klinik 3, Rheumatologie und Immunologie, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen
  • Koray Tascilar - Medizinische Klinik 3, Rheumatologie und Immunologie, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen
  • Julia Hühne - Medizinische Klinik 3, Rheumatologie und Immunologie, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen
  • Veronika Nees - Medizinische Klinik 3, Rheumatologie und Immunologie, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen
  • Axel Hueber - Rheumatologie, Sozialstiftung Bamberg – Klinikum am Bruderwald, Bamberg
  • Jürgen Rech - Medizinische Klinik 3, Rheumatologie und Immunologie, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen
  • Georg Schett - Medizinische Klinik 3, Rheumatologie und Immunologie, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen
  • Arnd Kleyer - Medizinische Klinik 3, Rheumatologie und Immunologie, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen

Deutsche Gesellschaft für Rheumatologie. Deutsche Gesellschaft für Orthopädische Rheumatologie. Gesellschaft für Kinder- und Jugendrheumatologie. Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR). sine loco [digital], 15.-18.09.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocRA.44

doi: 10.3205/21dgrh130, urn:nbn:de:0183-21dgrh1300

Published: September 14, 2021

© 2021 Liphardt et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Introduction: Serum concentration of cartilage oligomeric matrix protein (COMP) is related to cartilage destruction in rheumatoid arthritis (RA) and shows a mechanosensitive response to ambulatory loads [1]. Individuals with positive anti-citrullinated protein antibody (ACPA+) status already show bone loss [2] but it is unclear if these individuals experience cartilage deterioration and how this relates to physical activity (PA). We tested whether soluble COMP levels in ACPA+ display the same acute response as RA patients to a 30-minutes walking exercise and explored the association of serum (s) COMP levels and PA.

Methods: RA patients (2010 ACR/EULAR criteria) and ACPA+ individuals were enrolled in the study after written informed consent. The study comprised three visits (baseline (Visit 1), 6 (Visit 2), and 12 months (Visit 3). During each visit, serum samples were collected after 30 minutes rest (pre) and at 0, 30, 60, and 120 minutes after a 30-minute walking exercise. sCOMP concentration was analyzed by ELISA (COMP® ELISA, AnaMar AB, Göteborg, Sweden). PA duration (hours) was measured using an activity monitor (SenseWear®, Bodymedia®, Inc., USA) for 7 days, and PA level (metabolic equivalent of the task (MET)) was quantified using the International Physical Activity Questionnaire (IPAQ). The response of sCOMP levels to the walking exercise and the association between PA and overall sCOMP concentrations were modelled using linear mixed-effects regression models.

Results: 28 RA and 22 ACPA+ patients participated in this trial. Table 1 [Tab. 1] summarizes patient demographics and outcome measures. sCOMP levels increased in response to the walking exercise in both groups, the acute response was not different in RA compared to ACPA+. Doubling of total physical activity is associated with an increase in sCOMP of 0.32 U/L (95%CI 0.09 to 0.54, p=0.006). ACPA+ individuals show an association between sCOMP concentration and physical activity duration (Figure 1 [Fig. 1]).

Conclusion: Pre-exercise sCOMP and the acute response to walking are similar in ACPA+ and RA. Physical activity duration appears to influence sCOMP in ACPA+. Given that acute sCOMP release was not different between ACPA+ and RA while overall sCOMP values are associated with physical activity level, the discrepancy between ACPA+ and RA for this association can be explained by qualitative differences in physical activity.

Disclosures: The authors declare no conflict of interested in relation to this study. The study was supported by Pfizer Pharma GmbH, Germany.

Outline

References

1.
Herger S, Vach W, Liphardt AM, Egloff C, Nüesch C, Mündermann A. Dose-response relationship between ambulatory load magnitude and load-induced changes in COMP in young healthy adults. Osteoarthritis Cartilage. 2019 Jan;27(1):106-13. DOI: 10.1016/j.joca.2018.09.002 External link
2.
Kleyer A, Finzel S, Rech J, Manger B, Krieter M, Faustini F, Araujo E, Hueber AJ, Harre U, Engelke K, Schett G. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann Rheum Dis. 2014 May;73(5):854-60. DOI: 10.1136/annrheumdis-2012-202958 External link