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Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

15.09. - 18.09.2021, virtuell

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Features of the course of rheumatoid arthritis: focus on diagnostic methods

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  • Olga Alekseeva - V.A. Nasonova Research Institute of Rheumatology, Diagnostic Department, Moscow
  • Danil Kudinsky - V.A. Nasonova Research Institute of Rheumatology, Diagnostic Department, Moscow
  • Aleksander Smirnov - V.A. Nasonova Research Institute of Rheumatology, Diagnostic Department, Moscow
  • Alexander Volkov - V.A. Nasonova Research Institute of Rheumatology, Diagnostic Department, Moscow
  • Eugene Nasonov - V.A. Nasonova Research Institute of Rheumatology, Moscow

Deutsche Gesellschaft für Rheumatologie. Deutsche Gesellschaft für Orthopädische Rheumatologie. Gesellschaft für Kinder- und Jugendrheumatologie. Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR). sine loco [digital], 15.-18.09.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocDI.18

doi: 10.3205/21dgrh036, urn:nbn:de:0183-21dgrh0368

Published: September 14, 2021

© 2021 Alekseeva et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Introduction: Rheumatoid arthritis (RA) - a chronic inflammatory disease, which leads to destructive changes and dysfunction of joints. Ultrasonography (US) is a well established technique for diagnosis and follow up in RA.

Objective(s): The objective is to identify the features of the course of rheumatoid arthritis using imaging methods.

Methods: 85 RA pts, mean age 53,0 [44,0; 61,0] yrs, mean disease duration 8 [4; 24] months were treated by Treat-To-Target concept. After first year of therapy management was following real clinical practice rules until the termination of the study (4 years FUP). The wrist, MCP2 and MCP3, PIP2, PIP3, MTP2 and MTP5 joints of the clinically dominant side were examined by US (GS and PD). Clinical, laboratory parameters and US examination was performed at baseline, at Mo 3, 6, 9 and 12. The X-ray was conducted before treatment, at 12 Mo and in the end of the study. Structural damage progression was evaluated by change in the Sharp van der Heijde score (ΔSHS) between baseline and 4 year.

We categorized pts into 2 groups according to duration of the course of the disease: 1) early RA (the duration of the disease is less than 12 months), 2) non-early RA (more than 12 months).

Results: 56 early RA pts (66%) and 29 non-early RA pts (34%) patients presented among the 85 patients with RA.

RA progression by 4 years the follow-up period was identified in 17 pts (30%) of early RA group and in 16 pts (55%) of non-early RA group.

RA progression by 4 years the follow-up period was identified in 39% of pts.

In non-early RA group the count of erosion at baseline, at 12Mo and 4 years was significantly higher than in early RA group (1 [0; 5] and 0 [0; 2], 2 [0; 6] and 0 [0; 3], 3 [2; 10] and 1 [0; 4], respectively, p=0.03, p=0.03 and p=0.001 respectively).

Also in non-early RA group the GS at 6 and 12Mo was significantly higher than in early RA group (5 [3; 8] and 3 [2; 7], 5 [3; 8] and 3 [1; 5], respectively, p=0.02 and p=0.02 respectively).

Conclusion: This study shows the importance of timely therapy in the development of destructive changes in RA.

Disclosures: None declared