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43. Kongress der Deutschen Gesellschaft für Rheumatologie, 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie, 25. Wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie

02.-05. September 2015, Bremen

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Association of hepatitis E virus and cryoglobulinemia

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  • Pischke Sven - Med Klinik I UKE, Gastroenterologie und Infektiologie, Hamburg
  • Jan H. Schirmer - Klinikum Bad Bramstedt, Klinik für Rheumatologie und Immunologie, Bad Bramstedt
  • Frank Moosig - Klinikum Bad Bramstedt, Klinik für Rheumatologie und Immunologie, Bad Bramstedt
  • Christof Iking-Konert - Universitätsklinikum Hamburg-Eppendorf, Med. Klinik III, Abt. Nephrologie und Rheumatologie, Hamburg

Deutsche Gesellschaft für Rheumatologie. Deutsche Gesellschaft für Orthopädische Rheumatologie. Gesellschaft für Kinder- und Jugendrheumatologie. 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR). Bremen, 02.-05.09.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. DocVK.09

doi: 10.3205/15dgrh235, urn:nbn:de:0183-15dgrh2355

Published: September 1, 2015

© 2015 Sven et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Introduction: Several extrahepatic manifestations have been observed in the context of acute or chronic hepatitis E virus infections. Recently a case indicated an association between HEV infection and cryoglobulinemia [1], but this observation still needs to be confirmed and clarified.

Methods: Stored serum samples of 68 German patients with cryogluobulinemia were retrospectively tested for anti HEV IgG (Wantai assay). Seroprevalence rates were compared in patients with essential cryoglobulinemia (n=33) and in patients with cryoglobulinemia secondary to various underlying conditions (n=35) using chi square test.

Results: Within the group of patients with essential cryoglobulinemia 46% (n=15) tested positive for anti HEV IgG, while in the group of patients with different underlying conditions 23% (n=8) tested positive (p=0.043).

Conclusion: Patients with essential cryoglobulinemia tested positive more frequently for anti HEV than patients with secondary cryoglobulinemia due to well defined causes. This indicates that development of cryoglobulinemia of unknown origin is a relevant extrahepatic manifestation of hepatitis E.

Outline

References

1.
Pischke S, Behrendt P, Manns MP, Wedemeyer H. HEV-associated cryoglobulinaemia and extrahepatic manifestations of hepatitis E. Lancet Infect Dis. 2014 Aug;14(8):678-9. DOI: 10.1016/S1473-3099(14)70823-0 External link