gms | German Medical Science

44. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen e. V. (DGPRÄC), 18. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen e. V. (VDÄPC)

12.09. - 14.09.2013, Münster

Spider silk as a bioshield to reduce periprosthetic fibrous capsule formation

Meeting Abstract

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  • presenting/speaker Philip Zeplin - Universitätsklinikum Leipzig, Abteilung für Plastische, Ästhetische und spezielle Handchirurgie, Leipzig, Deutschland
  • Axel Leimer - AMSilk GmbH, Planegg/Martinsried, Deutschland
  • Thomas Scheibel - Universität Bayreuth, Lehrstuhl für Biomaterialien, Bayreuth, Deutschland

Deutsche Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen. Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen. 44. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 17. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC). Münster, 12.-14.09.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocFV 62

doi: 10.3205/13dgpraec069, urn:nbn:de:0183-13dgpraec0698

Published: September 10, 2013

© 2013 Zeplin et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Though silicone implants have been employed for decades in diverse surgical applications the associated medical complications, such as capsule formation and –contraction have not yet been met. In order to veil the implant surface during the critical phase of foreign body reactions, medical grade silicone implants were homogeneously coated with a thin layer of recombinant spider silk protein and then submitted to in vitro and long-term in vivo biocompatibility assessment. Focusing on specific immunological reactions, more than thirty different parameters were analyzed. Exemplarily, silk coating inhibited fibroblast proliferation, collagen I synthesis and differentiation of monocytes into CD68-postive histiocytes. The coatings significantly reduced capsule thickness, post-operative inflammation, synthesis and re-modeling of extracellular matrix and expression of contracture-mediating factors. These observations give rise to the prospect that major post-operative complications after implantation of alloprosthetics, such as capsular fibrosis and contraction can be reduced considerably by pre-operative silk coating.