gms | German Medical Science

60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

German Society for Neuropathology and Neuroanatomy

26. - 28.08.2015, Berlin

Molecular Genetic Analysis of Primary CNS Lymphoma (PCNSL)

Meeting Abstract

  • corresponding author presenting/speaker Josefine Radke - CharitÚ, Neuropathology, Berlin, Germany
  • Agnieszka Korfel - CharitÚ, Hematology and Oncology, Berlin, Germany
  • Naveed Ishaque - German Cancer Research Center and National Center for Tumor Diseases, Division of Applied Bioinformatics, Heidelberg, Germany
  • Dilafruz Juraeva - German Cancer Research Center and National Center for Tumor Diseases, Division of Applied Bioinformatics, Heidelberg, Germany
  • Gnana Prakash Balasubramanian - German Cancer Research Center and National Center for Tumor Diseases, Division of Applied Bioinformatics, Heidelberg, Germany
  • Michael Hummel - CharitÚ, Pathology, Berlin, Germany
  • Clemens A. Schmitt - CharitÚ, Hematology and Oncology, Berlin, Germany
  • Ioannis Anagnostopoulos - CharitÚ, Pathology, Berlin, Germany
  • Korinna J÷hrens - CharitÚ, Pathology, Berlin, Germany
  • Christel Herold-Mende - University Hospital Heidelberg, Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg, Germany
  • Andreas von Deimling - University Hospital Heidelberg, Neuropathology, Heidelberg, Germany
  • Peter Vajkoczy - CharitÚ, Neurosurgery, Berlin, Germany
  • Martin Misch - CharitÚ, Neurosurgery, Berlin, Germany
  • Julia Onken - CharitÚ, Neurosurgery, Berlin, Germany
  • Dag Moskopp - Klinikum im Friedrichshain, Neurosurgery, Berlin, Germany
  • Awen Wang - Klinikum im Friedrichshain, Neurosurgery, Berlin, Germany
  • Andreas J÷dicke - Klinikum Neuk÷lln, Neurosurgery, Berlin, Germany
  • Otmar D. Wiestler - German Cancer Research Center, Chairman and Scientific Director, Heidelberg, Germany
  • Benedikt Brors - German Cancer Research Center and National Center for Tumor Diseases, Division of Applied Bioinformatics, Heidelberg, Germany
  • Stefan Wiemann - German Cancer Research Center, Division of Molecular Genome Analysis, Heidelberg, Germany
  • Frank L. Heppner - CharitÚ, Neuropathology, Berlin, Germany

Deutsche Gesellschaft fŘr Neuropathologie und Neuroanatomie. 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN). Berlin, 26.-28.08.2015. DŘsseldorf: German Medical Science GMS Publishing House; 2015. Doc15dgnnP50

doi: 10.3205/15dgnn74, urn:nbn:de:0183-15dgnn740

Published: August 25, 2015

© 2015 Radke et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Primary CNS lymphomas (PCNSL) are extranodal malignant B-cell lymphomas arising in and confined to the CNS in the absence of systemic lymphoma at the time of diagnosis, accounting for about 3–5% of primary brain tumours. Despite extensive research, the molecular alterations leading to the disease and the causes for confinement to the CNS have not yet been elucidated. To gain a more precise insight into the genetic landscape and pathogenesis of PCNSL and to identify substanially and prognostically relevant genetic alterations, we assembled a unique collection of primary lymphoma samples, totalling 22 matched pairs of tumour and peripheral blood. We utilized whole genome sequencing (WGS) and RNA sequencing (RNAseq) to obtain a comprehensive view of the molecular alterations in these tumors. Our data adds to the understanding of the pathogenesis of PCNSL.