Article
Molecular Genetic Analysis of Primary CNS Lymphoma (PCNSL)
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Published: | August 25, 2015 |
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Primary CNS lymphomas (PCNSL) are extranodal malignant B-cell lymphomas arising in and confined to the CNS in the absence of systemic lymphoma at the time of diagnosis, accounting for about 3–5% of primary brain tumours. Despite extensive research, the molecular alterations leading to the disease and the causes for confinement to the CNS have not yet been elucidated. To gain a more precise insight into the genetic landscape and pathogenesis of PCNSL and to identify substanially and prognostically relevant genetic alterations, we assembled a unique collection of primary lymphoma samples, totalling 22 matched pairs of tumour and peripheral blood. We utilized whole genome sequencing (WGS) and RNA sequencing (RNAseq) to obtain a comprehensive view of the molecular alterations in these tumors. Our data adds to the understanding of the pathogenesis of PCNSL.