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57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

German Society for Neuropathology and Neuroanatomy

12. - 15.09.2012, Erlangen

57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

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Cortical dysplasia in a hard-to-control epilepsy case

Meeting Abstract

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  • presenting/speaker Ma. Francisca Tristán Agundis - Hospital Psiquiátrico "Fray Bernardino Álvarez", Anatomic Pathology, Mexico City, Mexico
  • Gustavo Félix Vargas - Universidad La Salle, Mexico City, Mexico
  • Daniel Sebastian Totxo Guerrero - Universidad Nacional Autónoma de México, Facultad de Medicina, Mexico City, Mexico
  • Rosa Emma Alonso Zúñiga - Universidad Autónoma de San Luis Potosí, Mexico City, Mexico
  • Sandoval Paredes Josefina - Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez", Mexico City, Mexico
  • Macías Arriaga Silvia Gabriela - Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez", Mexico City, Mexico
  • Peralta Rodríguez Brenda - Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez", Mexico City, Mexico
  • Gelista Herrera Nohemí - Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez", Mexico City, Mexico
  • Rembao Bojórquez Daniel - Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez", Mexico City, Mexico

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie. 57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN). Erlangen, 12.-15.09.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12dgnnPP6.6

doi: 10.3205/12dgnn117, urn:nbn:de:0183-12dgnn1178

Published: September 11, 2012

© 2012 Tristán Agundis et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective: To study the histopathological findings in a hard-to-control epilepsy case.

Materials and Methods: We selected a case of a 22-year-old male patient from the National Institute of Neurology and Neurosurgery “Manuel Velasco Suárez”, with hard-to-control epilepsy diagnosis. We revised the clinical history, EEG and MRI studies, and the stereotxis biopsy. The tissues were formalin-fixed, paraffin-embedded, cut into 5–7 µm slices, and stained with hematoxylin-eosin and argentaffin techniques in order to perform photonic microscopy.

Results: EEG report focal mild dysfunction in left temporal and occipital areas. MRI shows dysplasia in temporal and parietal areas with hypointensity on T1 secuence, and hyperintensity on T2 weighted and FLAIR images and polymicrogyric patterns. He was submitted to surgical section of the left parietal cortex; the histopathological study reveals hypoxic areas, difuse microinfarctions, engrossment of the cortical region with eosinophylic neurons, vacuolated neuropil and slight gliosis, and cortical dysplasia.

Conclusions: The cortical dysplasia diagnosis is established. After surgery the patient persists with partial sensitive crisis of the right arm which had remitted with oxcarbazepine 600 mg b.i.d. and levetiracetam 500 mg b.i.d. Currently the patient has a satisfactory evolution with no seizures or any neurological focal signs.

Outline

References

1.
Blümcke, et al. The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia. 2011;52(1):158-174.
2.
Palmini A, Najm I, Avanzini G, et al. Terminology and Classification of the Cortical Dysplasias. Neurology. 2004;62(Suppl 3):S2-S8