Article
Therapeutic anticoagulation impacts MR morphologic recurrence patterns in glioblastoma – a matched-pair analysis
Auswirkung der therapeutischen Antikoagulation auf das morphologische MR-Rezidivmuster im Glioblastom – eine Matched-Pair-Analyse
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Published: | May 25, 2022 |
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Outline
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Objective: Glioblastoma (GBM) patients are at particularly high risk for thrombotic complications. In the event of a postoperative pulmonary embolism, therapeutic anticoagulation (tAC) is indispensable. The impact of therapeutic anticoagulation on recurrence pattern in GBM is unknown to date.
Methods: We conducted a matched-pair cohort analysis of 57 GBM patients with or without therapeutic anticoagulation that were matched for age, sex, gross total resection and MGMT methylation status in a ratio of 1:2. Patients characteristic and clinical course were evaluated using medical charts. MRI characteristics were evaluated by two independent authors blinded to the AC status.
Results: The morphologic MRI appearance in first GBM recurrence showed a significant higher presence of multifocal, midline crossing and sharp demarcated GBM recurrence patterns in patients with therapeutic anticoagulation compared to the matched control group. Although statistically non-significant, the therapeutic anticoagulation cohort showed increased survival.
Conclusion: Therapeutic anticoagulation induces significant morphologic changes in GBM recurrences. The underlying pathophysiology is discussed in this article but remains to be further elucidated.
Figure 1 [Fig. 1]