gms | German Medical Science

73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

29.05. - 01.06.2022, Köln

Risk assessment for the occurrence of seisures in meningioma microsurgery

Risikobewertung für das Auftreten von Krampfanfällen in der Meningeom-Mikrochirurgie

Meeting Abstract

  • presenting/speaker Johannes Naegeli - Universitätsklinikum Leipzig, Klinik und Poliklinik für Neurochirurgie, Leipzig, Deutschland
  • presenting/speaker Felix Arlt - Universitätsklinikum Leipzig, Klinik und Poliklinik für Neurochirurgie, Leipzig, Deutschland
  • Caroline Sander - Universitätsklinikum Leipzig, Klinik und Poliklinik für Neurochirurgie, Leipzig, Deutschland
  • Jürgen Meixensberger - Universitätsklinikum Leipzig, Klinik und Poliklinik für Neurochirurgie, Leipzig, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie. Köln, 29.05.-01.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocP126

doi: 10.3205/22dgnc438, urn:nbn:de:0183-22dgnc4384

Published: May 25, 2022

© 2022 Naegeli et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Objective: Seizure is a common symptom of meningioma that has a major impact on patients` quality of life. The purpose of this study is to identify pre- and postoperative risk factors for the occurrence of seizures and to evaluate the risk assessment with a modified STAMPE2 score.

Methods: The data of patients with resection of histologically confirmed meningioma at the University Hospital Leipzig from 2009 to 2018 were retrospectively examined. Univariant and multivariant analysis of a modified STAMPE2 score and factors influencing seizure outcome was performed.

Results: Of 396 patients analyzed, preoperative seizures occurred in 63 patients (15.9%) and postoperative seizures in 43 patients (10.9%). After neurosurgery, 12 of the 63 patients (19%) with preoperative seizures continued to have them, while 31 of 333 patients (9.3%) suffered from de-novo seizures. Independent risk factor for the occurrence of preoperative and postoperative seizures were the therapeutic use of antiepileptic drugs before surgery (OR 0.011 [95% CI: 0.003-0.040], p <0.001) and after surgery (OR 0.120 [95% CI: 0.025-0.568], p = 0.008). The STAMPE2 score (p = 0.797) showed no correlation with the occurrence of postoperative seizures.

Conclusion: High-risk patients, especially for post-operative seizures, could benefit from prophylactic antiepileptic treatment. Therefore, further scoring systems for risk classification and thus guided anticonvulsant treatment should be developed and evaluated.