Article
Risk assessment for the occurrence of seisures in meningioma microsurgery
Risikobewertung für das Auftreten von Krampfanfällen in der Meningeom-Mikrochirurgie
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Published: | May 25, 2022 |
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Objective: Seizure is a common symptom of meningioma that has a major impact on patients` quality of life. The purpose of this study is to identify pre- and postoperative risk factors for the occurrence of seizures and to evaluate the risk assessment with a modified STAMPE2 score.
Methods: The data of patients with resection of histologically confirmed meningioma at the University Hospital Leipzig from 2009 to 2018 were retrospectively examined. Univariant and multivariant analysis of a modified STAMPE2 score and factors influencing seizure outcome was performed.
Results: Of 396 patients analyzed, preoperative seizures occurred in 63 patients (15.9%) and postoperative seizures in 43 patients (10.9%). After neurosurgery, 12 of the 63 patients (19%) with preoperative seizures continued to have them, while 31 of 333 patients (9.3%) suffered from de-novo seizures. Independent risk factor for the occurrence of preoperative and postoperative seizures were the therapeutic use of antiepileptic drugs before surgery (OR 0.011 [95% CI: 0.003-0.040], p <0.001) and after surgery (OR 0.120 [95% CI: 0.025-0.568], p = 0.008). The STAMPE2 score (p = 0.797) showed no correlation with the occurrence of postoperative seizures.
Conclusion: High-risk patients, especially for post-operative seizures, could benefit from prophylactic antiepileptic treatment. Therefore, further scoring systems for risk classification and thus guided anticonvulsant treatment should be developed and evaluated.