gms | German Medical Science

73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

29.05. - 01.06.2022, Köln

Electrophoretic coating of electrodes with platinum nanoparticles reduces and stabilises impedance during deep brain stimulation in vitro and in vivo in a rat model

Elektrophoretische Beschichtung von Elektroden mit Platin-Neuropartikeln reduzieren und stabilisieren die Impedanz in vitro und in vivo in einem Rattenmodell während der tiefen Hirnstimulation

Meeting Abstract

  • Svilen Angelov - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Vaijayanthi Ramesh - Universitätsklinikum Essen, Technical Chemistry I and Center for Nanointegration, Essen, Deutschland
  • Christoph Rehbock - Universitätsklinikum Essen, Technical Chemistry I and Center for Nanointegration, Essen, Deutschland
  • Hans E. Heissler - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Mesbah Alam - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • presenting/speaker Kerstin Schwabe - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Stephan Barcikowski - Universitätsklinikum Essen, Technical Chemistry I and Center for Nanointegration, Essen, Deutschland
  • Joachim K. Krauss - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie. Köln, 29.05.-01.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocP095

doi: 10.3205/22dgnc405, urn:nbn:de:0183-22dgnc4056

Published: May 25, 2022

© 2022 Angelov et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Objective: Electrodes for neural stimulation and recording are used for the treatment of neurological disorders, including deep brain stimulation (DBS). Their features critically depend on impedance and interaction with brain tissue.

Methods: Platin-iridium electrodes were coated using pulsed-DC electrophoretic deposition of laser-generated platinum nanoparticles (PtNPs). Uncoated electrodes served as controls. Impedance of the electrodes was measured before and after surface coating. For the in-vitro study the effect of four weeks electric stimulation on electrode impedance was measured in 0.9% NaCl solution. For the in-vivo study electrodes were bilaterally implanted in the subthalamic nucleus (STN) of rats (n=8) with coated electrodes implanted in the left and uncoated electrodes in the right hemisphere. After two weeks of postoperative recovery the animals received chronic stimulation for four weeks and impedance was assessed after each stimulation week.

Results: Coating with PtNP significantly reduced electrode impedance (p<0.05). In vitro stimulation of four weeks did not affect impedance of coated electrodes. Only initially after intracranial implantation into the STN, the impedance of coated electrodes was enhanced, but returned to reduced values during four weeks stimulation. Both in-vitro and in-vivo coated electrodes showed lower impedance fluctuations during stimulation than uncoated electrodes (p<0.05).

Conclusion: Pulsed-DC electrophoretic deposition of laser-generated PtNPs leads to reduced impedance and improved electrode impedance stability, which may stabilize the long-term performance of DBS.