gms | German Medical Science

73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

29.05. - 01.06.2022, Köln

Article

Send article

The impact of previous nasal surgery and pain on sino-nasal outcome and quality of life after transsphenoidal endoscopic resection of pituitary adenomas

Der Einfluss von Nasen-Voroperationen und Schmerzen auf sinu-nasales Outcome und Lebensqualität nach transsphenoidaler endoskopischer Resektion von Hypophysenadenomen

Meeting Abstract

Search Medline for

  • presenting/speaker Witold X. Chmielewski - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Sebastian Walbrodt - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Ilonka Kreitschmann-Andermahr - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Oliver Gembruch - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Marvin Darkwah Oppong - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Philipp Dammann - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Ramazan Jabbarli - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Karsten H. Wrede - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Ulrich Sure - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Yahya Ahmadipour - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie. Köln, 29.05.-01.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocP060

doi: 10.3205/22dgnc371, urn:nbn:de:0183-22dgnc3718

Published: May 25, 2022

© 2022 Chmielewski et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Objective: The transnasal binostril endoscopic resection of pituitary adenomas is regarded as a minimally invasive treatment nowadays. However, sino-nasal outcome and quality of life (QoL) might still be impaired after the resection of pituitary adenomas, depending on patients' prior medical history and health status. A systematic postoperative comparison is required to assess differences in perceived sino-nasal outcome and QoL.

Methods: In this single-center observational study, we collected data from 98 patients (46 female, mean age: 54.37), operated between August 2016 and August 2021, at a three months follow-up after pituitary adenoma resection. We utilized dependent t-tests to compare patients with or without previous nasal surgery or pain with the sino-nasal outcome test for neurosurgery (SNOT-NC), which queries post-surgical sino-nasal outcome in several subdomains, and the QoL inventory Short Form (SF)-36.

Results: At the three-month follow-up, patients with previous nasal surgery (n = 22) showed an aggravated sino-nasal outcome in each SNOT-NC domain (all p ≤ .034). Moreover, QoL was reduced in patients with previous nasal surgery, as reflected in the mental health component score (MCS) of the SF-36 (p = .001) and several SF-36 subdomains (all p ≤ .036). Patients with pain before surgery (n = 19) showed increased visual impairment (p = .024; SNOT-NC) and ear/head discomfort (p = .044; SNOT-NC). Furthermore, a reduction of the physical health component score (PCS) of the SF-36 (p = .047), as well as further impairments in several SF36 subdomains (all p ≤ .035) were observed in these patients.

Conclusion: Our data show that patients with previous nasal surgery or pain before surgery have an increased risk of an aggravated sino-nasal outcome and QoL. To induce realistic patient expectations, these patients should be thoroughly informed about such potential consequences of transnasal neurosurgical procedures.