gms | German Medical Science

73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

29.05. - 01.06.2022, Köln

Sporadic multiple meningiomas harbor distinct driver mutations

Treibermutationen der sporadischen multiplen Meningeome

Meeting Abstract

  • presenting/speaker Insa Prilop - Carl Gustav Carus Universitätsklinikum, TU Dresden, Klinik und Poliklinik für Neurochirurgie, Dresden, Deutschland
  • Felix C. Saalfeld - Carl Gustav Carus Universitätsklinikum, TU Dresden, Institut für Pathologie, Dresden, Deutschland
  • Matthias Meinhardt - Carl Gustav Carus Universitätsklinikum, TU Dresden, Institut für Pathologie, Dresden, Deutschland
  • Carina Wenzel - Carl Gustav Carus Universitätsklinikum, TU Dresden, Institut für Pathologie, Dresden, Deutschland
  • Sylvia Herold - Carl Gustav Carus Universitätsklinikum, TU Dresden, Institut für Pathologie, Dresden, Deutschland
  • Silke Zeugner - Carl Gustav Carus Universitätsklinikum, TU Dresden, Institut für Pathologie, Dresden, Deutschland
  • Daniela E. Aust - Carl Gustav Carus Universitätsklinikum, TU Dresden, Institut für Pathologie, Dresden, Deutschland
  • Gabriele Schackert - Carl Gustav Carus Universitätsklinikum, TU Dresden, Klinik und Poliklinik für Neurochirurgie, Dresden, Deutschland
  • Thomas Pinzer - Carl Gustav Carus Universitätsklinikum, TU Dresden, Klinik und Poliklinik für Neurochirurgie, Dresden, Deutschland
  • Tareq Juratli - Carl Gustav Carus Universitätsklinikum, TU Dresden, Klinik und Poliklinik für Neurochirurgie, Dresden, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie. Köln, 29.05.-01.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocV306

doi: 10.3205/22dgnc294, urn:nbn:de:0183-22dgnc2947

Published: May 25, 2022

© 2022 Prilop et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Objective: Multiple meningiomas (MM) are rare and present a unique management challenge. While the mutational landscape of single meningiomas has been extensively studied, understanding of the molecular pathogenesis of sporadic MM remains incomplete. The objective of this study is to elucidate the genetic features of sporadic MM.

Methods: We identified eight patients with MM (n=17) defined as ≥2 spatially separated synchronous or metachronous meningiomas. We profiled genetic changes in these tumors using a next generation sequencing (NGS) assay that covers a large number of targetable and frequently mutated genes in meningiomas including AKT1, KLF4, NF2, PIK3CA/PIK3R1, POLR2A, SMARCB1, SMO, SUFU, TRAF7, and the TERT promoter.

Results: Most of MM were WHO grade 1 (n= 14, 82.3%). Within individual patients, no driver mutation was shared between separate tumors. All but two cases harbored different hot spot mutations in known meningioma-driver genes like TRAF7 (n= 5), PIK3CA (n= 3), AKT1 (n= 3) and SMO (n= 1). Moreover, individual tumors differed in histologic subtype in 7/8 patients. The low frequency of NF2 mutations in our series stands in contrast to previous studies that included hereditary cases arising in the setting of neurofibromatosis type 2 (NF2).

Conclusion: Our findings provide evidence for genomic inter-tumor heterogeneity and an independent molecular origin of sporadic NF2 wild-type MM. Furthermore, these findings suggest that genetic characterization of each lesion is warranted in sporadic MM.