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73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

29.05. - 01.06.2022, Köln

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Perifocal edema in meningioma patients is correlated with impaired whole brain connectivity as detected by resting-state functional MRI

Perifokalödem bei Meningeompatienten korreliert mit Beeiträchtigung der funktionellen Konnektivität im resting-state fMRT

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  • presenting/speaker Veit Stöcklein - Klinikum der Ludwig-Maximilians-Universität München, Neurochirurgische Klinik und Poliklinik, München, Deutschland; Deutsches Krebsforschungszentrum (DKFZ), Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partnerstandort München, München, Deutschland
  • Stephan Wunderlich - Klinikum der Ludwig-Maximilians-Universität München, Klinik und Poliklinik für Radiologie, München, Deutschland
  • Boris Papazov - Klinikum der Ludwig-Maximilians-Universität München, Klinik und Poliklinik für Radiologie, München, Deutschland
  • Michael Schmutzer - Klinikum der Ludwig-Maximilians-Universität München, Neurochirurgische Klinik und Poliklinik, München, Deutschland
  • Christian Schichor - Klinikum der Ludwig-Maximilians-Universität München, Neurochirurgische Klinik und Poliklinik, München, Deutschland
  • Niklas Thon - Klinikum der Ludwig-Maximilians-Universität München, Neurochirurgische Klinik und Poliklinik, München, Deutschland
  • Hesheng Liu - Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Boston, MA, Vereinigte Staaten
  • Jörg-Christian Tonn - Klinikum der Ludwig-Maximilians-Universität München, Neurochirurgische Klinik und Poliklinik, München, Deutschland; Deutsches Krebsforschungszentrum (DKFZ), Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partnerstandort München, München, Deutschland
  • presenting/speaker Sophia Stöcklein - Klinikum der Ludwig-Maximilians-Universität München, Klinik und Poliklinik für Radiologie, München, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie. Köln, 29.05.-01.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocV047

doi: 10.3205/22dgnc054, urn:nbn:de:0183-22dgnc0548

Published: May 25, 2022

© 2022 Stöcklein et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Resting-state functional MRI (rsfMRI) can be used to assess whole brain functional connectivity and has been shown to serve as a marker for disease severity in glioma patients. However, it is unclear whether extraaxial tumors such as intracranial meningeomas might lead to comparable effects. In addition, the role of perifocal edema indicating irritation and potential dysfunction of the adjacent brain remains to be determined. Here, we investigated whether meningeomas with and without preoperative perifocal brain edema lead to impaired functional connectivity.

Methods: Patients with suspected meningioma were prospectively included. Data of preoperative functional resting state MRI were processed according to our recently published protocol and individual abnormality of functional connectivity was quantified. This was correlated with both tumor and edema volume as well as MOCA test score as an indicator of neurocognitive performance. Correlations were analysed with Spearman’s test, in addition a generalized linear model (GLM) was used.

Results: 29 patients were included, 14/29 patients had perifocal edema. There was a highly significant positive correlation of edema volume and abnormal functional connectivity (p=0.0174, r=0.41976, in GLM p=0.0002). In contrast, tumor volume was not correlated with abnormal functional connectivity in a GLM, therefore no statistically significant association with tumor volume was found. Interestingly, there was a highly significant correlation between better neurocognitive performance as indicated by MOCA test scores and lower abnormality of functional connectivity (p=0.0203, r=-0.44425; GLM p=0.0023).

Conclusion: In meningioma patients rsfMRI showed a significant correlation between abnormal functional connectivity and perifocal edema but not with meningioma volume. Better neurocognitive function was associated with less abnormal functional connectivity. This might indicate that in meningioma patients perifocal edema is one main driver of functional relevant impairment of whole brain connectivity as detected by rsfMRI.