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73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

29.05. - 01.06.2022, Köln

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Spatio-temporal resolution of stereo-EEG signals following olfactory stimulation

Zeitliche und räumliche Auflösung der SEEG Signale nach der Stimulation mittels olfaktorischer Stimulation

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  • presenting/speaker Dino Podlesek - Carl Gustav Carus Universitätsklinikum, TU Dresden, Klinik und Poliklinik für Neurochirurgie, Dresden, Deutschland
  • Coralie Mignot - Carl Gustav Carus Universitätsklinikum, TU Dresden, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Interdisziplinäres Zentrum für Riechen und Schmecken, Dresden, Deutschland
  • Susanne Menzel - Carl Gustav Carus Universitätsklinikum, TU Dresden, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Interdisziplinäres Zentrum für Riechen und Schmecken, Dresden, Deutschland
  • Georg Leonhardt - Carl Gustav Carus Universitätsklinikum, TU Dresden, Klinik und Poliklinik für Neurochirurgie, Dresden, Deutschland
  • Thomas Hummel - Carl Gustav Carus Universitätsklinikum, TU Dresden, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Interdisziplinäres Zentrum für Riechen und Schmecken, Dresden, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie. Köln, 29.05.-01.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocV026

doi: 10.3205/22dgnc026, urn:nbn:de:0183-22dgnc0269

Published: May 25, 2022

© 2022 Podlesek et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Dynamics of olfactory processing and the role of neural oscillations have received little attention in humans. We report intracranial recordings of temporo-spatial oscillations using stereo-electroencephalography (SEEG) following olfactory stimulation.

Methods: One patient (34 yrs.) with medical resistant epilepsy was monitored by SEEG. Peach and fish odor were presented in 2 sessions separated by 5 days. Using MatLab based software we analyzed odor-induced changes in theta, beta, and gamma frequency bands from bilateral recordings from amygdala, hippocampus, temporo-occipital regions, temporo-medial gyrus and parahippocampal gyrus.

Results: There were similar odor-induced oscillation patterns in both sessions in the left Hippocampus, left parahippocampal gyrus, left temporooccipital lobe and predominantly right hippocampus and parahippocampal gyrus. However, in the second session, oscillations were weaker for repeated stimuli, a mechanism known as long-term central adaptation. The high frequency bilateral oscillations in amygdala, parahippocampus and hippocampus suggested higher-level, cognition-related processing of olfactory information.

Conclusion: We report an investigation of the human olfactory network characterized by typical spatio-temporal patterns of neuronal oscillations. The identified characteristic oscillatory response to odors is consistent by the sparse literature. The results are expected to promote the development of implants that can electrically induce olfactory perceptions in patients without a sense of smell.

Funding: This research received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 964529